GeneTex

  • Country / Location Selection

United States (US)

LILRB4 antibody

KO/KD Orthogonal
Anti-LILRB4 antibody used in Western Blot (WB). GTX33296
Anti-LILRB4 antibody used in IHC (Paraffin sections) (IHC-P). GTX33296
Anti-LILRB4 antibody used in IHC (Paraffin sections) (IHC-P). GTX33296
Anti-LILRB4 antibody used in IHC (Paraffin sections) (IHC-P). GTX33296
Anti-LILRB4 antibody used in Western Blot (WB). GTX33296
Anti-LILRB4 antibody used in Western Blot (WB). GTX33296
Anti-LILRB4 antibody used in Western Blot (WB). GTX33296
Anti-LILRB4 antibody used in Western Blot (WB). GTX33296

Cat. No. GTX33296

Reference 2

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC-P

Reactivity

 Human, Mouse
Package
100 μl ($399)
See all LILRB4 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:500 - 1:2000
IHC-P 1:50 - 1:200
Not tested in other applications.

Calculated MW

49 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS, 50% Glycerol

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 22-259 of human LILRB4 (NP_001265355.2).

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

RRID

AB_2887707

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

leukocyte immunoglobulin like receptor B4 , CD85K , ILT-3 , ILT3 , LIR-5 , LIR5

Cellular Localization

Cell membrane

Background

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. The receptor can also function in antigen capture and presentation. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-LILRB4 antibody used in Western Blot (WB). GTX33296

GTX33296 WB Image

WB analysis of various sample lysates using GTX33296 LILRB4 antibody.
Dilution : 1:1000
Loading : 25μg per lane

Anti-LILRB4 antibody used in IHC (Paraffin sections) (IHC-P). GTX33296

GTX33296 IHC-P Image

IHC-P analysis of human liver cancer tissue using GTX33296 LILRB4 antibody.
Dilution : 1:100

Anti-LILRB4 antibody used in IHC (Paraffin sections) (IHC-P). GTX33296

GTX33296 IHC-P Image

IHC-P analysis of mouse spleen tissue using GTX33296 LILRB4 antibody.
Blue : DAPI
Dilution : 1:100

Anti-LILRB4 antibody used in IHC (Paraffin sections) (IHC-P). GTX33296

GTX33296 IHC-P Image

IHC-P analysis of human colon carcinoma tissue using GTX33296 LILRB4 antibody.
Dilution : 1:100

Anti-LILRB4 antibody used in Western Blot (WB). GTX33296

GTX33296 WB Image

KO/KD

The data was published in the journal Biosci Rep in 2019. PMID: 31138763

Anti-LILRB4 antibody used in Western Blot (WB). GTX33296

GTX33296 WB Image

Orthogonal

The data was published in the journal Biosci Rep in 2019. PMID: 31138763

Anti-LILRB4 antibody used in Western Blot (WB). GTX33296

GTX33296 WB Image

Orthogonal

The data was published in the journal Biosci Rep in 2019. PMID: 31138763

Anti-LILRB4 antibody used in Western Blot (WB). GTX33296

GTX33296 WB Image

The data was published in the journal Biosci Rep in 2019. PMID: 31138763

REFERENCE

Application Reference

Wang Y et al. Cell Rep Med 2024; 5 (1) : 101374 Discovery of galectin-8 as an LILRB4 ligand driving M-MDSCs defines a class of antibodies to fight solid tumors.
Qiu T et al. Biosci Rep 2019; 39 (6) Leukocyte immunoglobulin-like receptor B4 deficiency exacerbates acute lung injury via NF-庥B signaling in bone marrow-derived macrophages.
Application : WB
Reactivity : Mouse
Submit a Reference

REVIEW

There are currently no reviews for LILRB4 antibody (GTX33296). Be the first to share your experience with this product.
Submit a Review
SDS
PBS.pdf
Glycerol.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399