*Optimal dilutions/concentrations should be determined by the researcher.
Human Cerebral Cortex shows lysosomal staining.
Not tested in other applications.
The peptide used to generate this antibody is available for purchase (GTX88440-PEP).
This antibody is expected to recognize reported isoform 1 (NP_005497.1) only.
Tris saline pH7.3, 0.02% sodium azide, 0.5% BSA.
Peptide with sequence C-NKANIQFGDNGTTIS, from the internal region of the protein sequence according to NP_005497.1.
Purified by ammonium sulphate precipitation followed by antigen affinity chromatography
For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
LIMPII Antibody , SR BII Antibody , EPM4 Antibody , AMRF Antibody , HLGP85 Antibody , LGP85 Antibody , SCARB2 Antibody , LIMP2 Antibody , CD36L2 Antibody
The protein encoded by this gene is a type III glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes. Earlier studies in mice and rat suggested that this protein may participate in membrane transportation and the reorganization of endosomal/lysosomal compartment. The protein deficiency in mice was reported to impair cell membrane transport processes and cause pelvic junction obstruction, deafness, and peripheral neuropathy. Further studies in human showed that this protein is a ubiquitously expressed protein and that it is involved in the pathogenesis of HFMD (hand, foot, and mouth disease) caused by enterovirus-71 and possibly by coxsackievirus A16. Mutations in this gene caused an autosomal recessive progressive myoclonic epilepsy-4 (EPM4), also known as action myoclonus-renal failure syndrome (AMRF). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011]
GTX88440 IHC-P Image
IHC-P analysis of human cerebral cortex using GTX88440 LIMP II antibody, Internal.
Antigen retrieval : citrate buffer pH 6
Dilution : 3.8µg/ml
GTX88440 WB Image
WB analysis of human cerebral cortex lysate using GTX88440 LIMP II antibody, Internal.
Dilution : 0.1µg/ml
Loading : 35µg protein in RIPA buffer