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LKB1 (phospho Ser428) antibody

Anti-LKB1 (phospho Ser428) antibody used in IHC (Paraffin sections) (IHC-P). GTX30765
Anti-LKB1 (phospho Ser428) antibody used in Western Blot (WB). GTX30765

Cat No. GTX30765

Host

Rabbit

Clonality

Polyclonal

Isotype

IgG

Application

WB, IHC-P

Reactivity

Human, Mouse, Monkey
Package
50 μl ($289)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1:500 - 1:1000
IHC-P 1:50 - 1:100
Not tested in other applications.

Calculated MW

49 kDa. ( Note )

Predict Reactivity

Rat(>80% identity)

PROPERTIES

Form

Liquid

Buffer

PBS (without Mg²⁺ and Ca²⁺) pH 7.4, 150mM NaCl, 0.02% sodium azide, 50% glycerol

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

The antiserum was produced against synthesized phosphopeptide derived from human LKB1 around the phosphorylation site of serine 428 (R-L-Sp-A-C).

Purification

Purified by sequential chromatography on phospho- and non-phospho-peptide affinity columns.
From serum

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

LKB1,PJS,STK11,hLKB1,serine/threonine kinase 11

Cellular Localization

Nucleus,Cytoplasm,Membrane,Mitochondrion

Background

This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-LKB1 (phospho Ser428) antibody used in IHC (Paraffin sections) (IHC-P). GTX30765

GTX30765 IHC-P Image

IHC-P analysis of human breast carcinoma tissue using GTX30765 LKB1 (phospho Ser428) antibody.

Anti-LKB1 (phospho Ser428) antibody used in Western Blot (WB). GTX30765

GTX30765 WB Image

WB analysis of CV-1 cells treated with forsklin lysate using GTX30765 LKB1 (phospho Ser428) antibody.
Left : Primary antibody
Right : Primary antibody preincubated with immunogen peptide

REFERENCE

REVIEW

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Package List Price ($)
$ 289