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LOXL1 antibody

Anti-LOXL1 antibody used in IHC (Whole mount) (IHC-Wm). GTX114532

Cat. No. GTX114532

Reference 4

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC-Wm

Reactivity

 Human, Zebrafish
Package
100 μl ($399),
25 μl ($169)
See all LOXL1 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB Assay dependent
IHC-Wm Assay dependent
Not tested in other applications.

Calculated MW

63 kDa. ( Note )

Predict Reactivity

Mouse, Rat, Bovine, Xenopus tropicalis(>80% identity)

PROPERTIES

Form

Liquid

Buffer

PBS, 1% BSA, 20% Glycerol

Preservative

0.01% Thimerosal

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant protein encompassing a sequence within the center region of human LOXL1. The exact sequence is proprietary.

Purification

Purified by antigen-affinity chromatography.

Conjugation

Unconjugated

RRID

AB_11179538

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

lysyl oxidase like 1 , LOL , LOXL

Cellular Localization

Secreted , extracellular space

Background

This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. [provided by RefSeq]

Database

Research Area

DATA IMAGES

Anti-LOXL1 antibody used in IHC (Whole mount) (IHC-Wm). GTX114532

GTX114532 IHC-Wm Image

Immunofluorescent image of a cross-section of a zebrafish embryo using LOXL1 antibody (GTX114532) at a 1:200 dilution. LOXL1(Blue) a-Tubulin(Red)(This image was provided courtesy of the Schilling Lab at UC, Irvine.)

REFERENCE

Application Reference

Xu C et al. Gene 2021; 766 : 145149 Effect of mechanical injury and IL-1β on the expression of LOXs and MMP-1, 2, 3 in PCL fibroblasts after co-culture with synoviocytes.
Application : WB
Reactivity : Human
Wang C et al. Biotechnol Lett 2020; 42 (8) : 1567-1579 Mechanical injury and IL-1β regulated LOXs and MMP-1, 2, 3 expression in ACL fibroblasts co-cultured with synoviocytes.
Application : WB
Reactivity : Human
Wang C et al. Connect Tissue Res 2018; : 43112 Different expression profiles of the lysyl oxidases and matrix metalloproteinases in human ACL fibroblasts after co-culture with synovial cells.
Application : WB
Reactivity : Human
Jung IH et al. Tissue Eng Part A 2012; 18 (43226) : 643-53 Novel application of human periodontal ligament stem cells and water-soluble chitin for collagen tissue regeneration: in vitro and in vivo investigations.
Application : WB
Submit a Reference

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SDS
PBS.pdf
Glycerol.pdf
Thimerosal.pdf
Package List Price ($)
$ 399
$ 169