APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| 1 - 2 μg/mL |
| 2.5 μg/mL |
| Assay dependent |
Not tested in other applications.
Calculated MW
Positive Control
Human Brain Tissue Lysate(GTX27918)
Product Note
This antibody is predicted to not cross-react with other members of the LRFN family.
PROPERTIES
Form
Liquid
Buffer
PBS
Preservative
0.02% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
1 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
LRFN1 antibody was raised against an 18 amino acid synthetic peptide near the carboxy terminus of human LRFN1.The immunogen is located within amino acids 700 - 750 of LRFN1.
Purification
Purified by antigen-affinity chromatography
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
leucine rich repeat and fibronectin type III domain containing 1 , SALM2
Cellular Localization
Membrane,Cell junction, synapse
Background
LRFN1 is one of a family of five transmembrane glycoproteins that are highly expressed in neuronal tissues. LRFN proteins share leucine-rich repeat (LRR)-immunoglobulin-like (Ig)-fibronectin type III (Fn)-transmembrane domain structure with other members of the LRR-Ig-Fn protein superfamily such as the Slitrk family of proteins. Expression of LRFN1, -3, and -4 mRNA was detected in embryonic neuronal cells, while Lrfn2 and Lrfn5 expression was primarily restricted to more mature cells. LRFN1, -2, and -4 bound to PDZ domains of postsynaptic PSD95, re-distributing PSD95 to the cell periphery. It has been suggested that the Lrfn proteins play a role in the developing and/or mature vertebrate nervous system. At least two isoforms of LRFN1 are known to exist. This antibody is predicted to not cross-react with other members of the LRFN family.
Database
Research Area
DATA IMAGES
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GTX85345 WB Image
WB analysis of human brain tissue lysate using GTX85345 LRFN1 antibody.
Working concentration : (A) 1 and (B) 2 μg/ml
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GTX85345 IHC-P Image
IHC-P analysis of mouse brain tissue using GTX85345 LRFN1 antibody.
Working concentration : 2.5 μg/ml
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GTX85345 IHC-P Image
IHC-P analysis of mouse brain tissue using GTX85345 LRFN1 antibody.
Working concentration : 20 μg/ml
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REFERENCE
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REVIEW
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