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LRP1 antibody [5A6] (Biotin)

Cat No. GTX79839

Host

Mouse

Clonality

Monoclonal

Clone Name

5A6

Isotype

IgG2b

Application

WB, ICC/IF, IHC-P, IHC-Fr, FACS, IP, ELISA

Reactivity

Human, Mouse, Rabbit
Package
100 μg ($339)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB Assay dependent
ICC/IF Assay dependent
IHC-P Assay dependent
IHC-Fr Assay dependent
FACS Assay dependent
IP Assay dependent
ELISA Assay dependent
Not tested in other applications.

Calculated MW

505 kDa. ( Note )

Product Note

Recognises the 85kDa cleaved fragment of Low Density LRP (extracellular domain).

PROPERTIES

Form

Liquid

Buffer

0.05M Sodium Phosphate pH6.6, 0.1M NaCl, 1mM EDTA

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

5 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Full length native protein (purified) (Human).

Purification

Protein A purified

Conjugation

Biotin

RRID

AB_11168727

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

A2MR,APOER,APR,CD91,IGFBP3R,LDL receptor related protein 1,LRP,LRP1,LRP1A,TGFBR5

Cellular Localization

Cell membrane,Membrane,Coated pit,Cytoplasm,Nucleus

Background

This gene encodes a member of the low-density lipoprotein receptor family of proteins. The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712). This receptor is involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the alpha 2-macroglobulin-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer's disease patients. [provided by RefSeq, Oct 2015]

Database

Research Area

REFERENCE

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REVIEW

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Package List Price ($)
$ 339