APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Dilution |
| Assay dependent |
| Assay dependent |
| Assay dependent |
| Assay dependent |
| Assay dependent |
| Assay dependent |
| Assay dependent |
Not tested in other applications.
Calculated MW
Product Note
Recognises the 85kDa cleaved fragment of Low Density LRP (extracellular domain).
PROPERTIES
Form
Liquid
Buffer
0.05M Sodium Phosphate pH6.6, 0.1M NaCl, 1mM EDTA
Preservative
No preservative
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
5 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
Full length native protein (purified) (Human).
Purification
Protein A purified
Conjugation
Biotin
RRID
AB_11168727
Note
For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET
Synonyms
A2MR,APOER,APR,CD91,IGFBP3R,LDL receptor related protein 1,LRP,LRP1,LRP1A,TGFBR5
Cellular Localization
Cell membrane,Membrane,Coated pit,Cytoplasm,Nucleus
Background
This gene encodes a member of the low-density lipoprotein receptor family of proteins. The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712). This receptor is involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the alpha 2-macroglobulin-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer's disease patients. [provided by RefSeq, Oct 2015]
Database
Research Area
REFERENCE
There are currently no references for LRP1 antibody [5A6] (Biotin) (GTX79839). Be the first to share your publications with this product.
REVIEW
There are currently no reviews for LRP1 antibody [5A6] (Biotin) (GTX79839). Be the first to share your experience with this product.
