*Optimal dilutions/concentrations should be determined by the researcher.
Not tested in other applications.
Recognises the 515kDa alpha chain of Low Density LRP/alpha-2-macroglobulin receptor.
0.05M Sodium Phosphate pH6.6, 0.1M NaCl, 1mM EDTA
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. Protect from light.
5 mg/ml (Please refer to the vial label for the specific concentration.)
Full length native protein (purified) (Human).
Protein A purified
Fluorescein isothiocyanate (FITC)
For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
A2MR,APOER,APR,CD91,IGFBP3R,LDL receptor related protein 1,LRP,LRP1,LRP1A,TGFBR5
Cell membrane,Membrane,Coated pit,Cytoplasm,Nucleus
This gene encodes a member of the low-density lipoprotein receptor family of proteins. The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712). This receptor is involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the alpha 2-macroglobulin-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer's disease patients. [provided by RefSeq, Oct 2015]