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LRP1 antibody [8G1]

Cat No. GTX79843

Host

Mouse

Clonality

Monoclonal

Clone Name

8G1

Isotype

IgG1

Application

WB, ICC/IF, IHC-P, IHC-Fr, FACS, Dot, EM, Neutralizing/Inhibition

Reactivity

Human
Package
500 μg ($319)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB Assay dependent
ICC/IF Assay dependent
IHC-P Assay dependent
IHC-Fr Assay dependent
FACS Assay dependent
Dot Assay dependent
EM Assay dependent
Neutralizing/Inhibition Assay dependent
Not tested in other applications.

Calculated MW

505 kDa. ( Note )

Product Note

Recognises the 515kDa alpha chain of Low Density LRP/alpha-2-macroglobulin receptor.

PROPERTIES

Form

Liquid

Buffer

0.05M Sodium Phosphate pH6.6, 0.1M NaCl, 1mM EDTA

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

5 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Full length native protein (purified) (Human).

Purification

Protein A purified
From tissue culture supernatant

Conjugation

Unconjugated

RRID

AB_11176350

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

A2MR,APOER,APR,CD91,IGFBP3R,LDL receptor related protein 1,LRP,LRP1,LRP1A,TGFBR5

Cellular Localization

Cell membrane,Membrane,Coated pit,Cytoplasm,Nucleus

Background

This gene encodes a member of the low-density lipoprotein receptor family of proteins. The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712). This receptor is involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the alpha 2-macroglobulin-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer's disease patients. [provided by RefSeq, Oct 2015]

Database

Research Area

REFERENCE

REVIEW

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Package List Price ($)
$ 319