GeneTex

  • Country / Location Selection

United States (US)

LRP1 antibody [8G1]

Cat. No. GTX79843

Reference 3

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 8G1

Isotype

 IgG1

Application

 WB, ICC/IF, IHC-P, IHC-Fr, FACS, Dot, EM, Neutralizing/Inhibition

Reactivity

 Human
Package
500 μg ($399)
See all LRP1 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB Assay dependent
ICC/IF Assay dependent
IHC-P Assay dependent
IHC-Fr Assay dependent
FACS Assay dependent
Dot Assay dependent
EM Assay dependent
Neutralizing/Inhibition Assay dependent
Not tested in other applications.

Calculated MW

505 kDa. ( Note )

Product Note

Recognises the 515kDa alpha chain of Low Density LRP/alpha-2-macroglobulin receptor.

PROPERTIES

Form

Liquid

Buffer

50mM Sodium Phosphate, 100mM NaCl, 1mM EDTA

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

5 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Full length native protein (purified) (Human).

Purification

Protein A purified
From tissue culture supernatant

Conjugation

Unconjugated

RRID

AB_11176350

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

A2MR,APOER,APR,CD91,IGFBP3R,LDL receptor related protein 1,LRP,LRP1,LRP1A,TGFBR5

Cellular Localization

Cell membrane,Membrane,Coated pit,Cytoplasm,Nucleus

Background

This gene encodes a member of the low-density lipoprotein receptor family of proteins. The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712). This receptor is involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the alpha 2-macroglobulin-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer's disease patients. [provided by RefSeq, Oct 2015]

Database

Research Area

REFERENCE

Application Reference

Boel NM et al. Sci Rep 2018; 8 (1) : 11438 LRP1 is required for novobiocin-mediated fibronectin turnover.
Application : WB
Reactivity : Human
Leone P et al. Blood 2015; 126 (12) : 1443-51 Dendritic cells accumulate in the bone marrow of myeloma patients where they protect tumor plasma cells from CD8+ T-cell killing.
Application : FACS
Reactivity : Human

Clone Reference

Sivasoorian SS et al. Pharmaceutics 2022; 14 (9) Neuropeptide-Functionalized Gold Nanorod Enhanced Cellular Uptake and Improved In Vitro Photothermal Killing in LRP1-Positive Glioma Cells.
Submit a Reference

REVIEW

There are currently no reviews for LRP1 antibody [8G1] (GTX79843). Be the first to share your experience with this product.
Submit a Review
Package List Price ($)
$ 399