LRP2 antibody

Cat. No. GTX04759

Host	Rabbit
Clonality	Polyclonal
Isotype	IgG
Application	ICC/IF, IHC-P, FACS
Reactivity	Human, Mouse
Package	100 μl ($399)

See all LRP2 products

Datasheet

View product citations for antibody GTX04759 on CiteAb

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.

Application	Recommended Dilution
ICC/IF	1:50-1:200
IHC-P	1:200-1:400
FACS	1:20-1:100

Not tested in other applications.

Calculated MW

522 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

0.01M TBS, 1% BSA, 50% Glycerol

Preservative

0.02% Proclin300

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

KLH conjugated synthetic peptide derived from human Megalin (aa 3401-3500)

Purification

Protein A purified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

DBS,GP330,LDL receptor related protein 2,LRP2,Lrp2,Megalin

Cellular Localization

Membrane,Coated pit

Background

The protein encoded by this gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones. This protein also has a role in cell-signaling; extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of this membrane receptor is regulated by phosphorylation of its cytoplasmic domain. Mutations in this gene cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR).[provided by RefSeq, Aug 2009]

Database

Gene ID: 4036 LRP2
UniProt: P98164 LRP2

Research Area

DATA IMAGES

GTX04759 IHC-P Image

IHC-P analysis of human lung carcinoma using GTX04759 LRP2 antibody.
Dilution : 1:200

GTX04759 FACS Image

FACS analysis of mouse kidney cells using GTX04759 LRP2 antibody.
Green : Primary antibody
Orange : Isotype control
Blue : Secondary antibody only
Black : Unlabeled cells
Dilution : 1:50

REFERENCE

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REVIEW

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Package

List Price ($)

100 μl

$ 399

Qty