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Laforin antibody, Internal

Anti-Laforin antibody, Internal used in IHC (Paraffin sections) (IHC-P). GTX88479
Anti-Laforin antibody, Internal used in Western Blot (WB). GTX88479

Cat No. GTX88479

Host

Goat

Clonality

Polyclonal

Isotype

IgG

Application

WB, IHC-P

Reactivity

Human
Package
100 μg ($369)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 0.1-0.3μg/ml
IHC-P 2.5-3.8μg/ml

Note :

IHC-P
Human Cerebellum shows pixulate staining in the cells of the granular layer.

Not tested in other applications.

Calculated MW

37 kDa. ( Note )

Positive Control

The peptide used to generate this antibody is available for purchase (GTX88479-PEP).

Product Note

This antibody is expected to recognize isoform a (NP_005661.1) only.

Predict Reactivity

Mouse, Rat, Bovine, Dog(>80% identity)

PROPERTIES

Form

Liquid

Buffer

TBS pH7.3, 0.5% BSA

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.50 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Peptide with sequence C-EATGHTNEMKHTTD, from the internal region of the protein sequence according to NP_005661.1.

Purification

Purified by ammonium sulphate precipitation followed by antigen affinity chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

EPM2A glucan phosphatase, laforin , EPM2 , MELF

Cellular Localization

Cytoplasm , Endoplasmic reticulum membrane , Cell membrane , Nucleus

Background

This gene encodes a dual-specificity phosphatase and may be involved in the regulation of glycogen metabolism. The protein acts on complex carbohydrates to prevent glycogen hyperphosphorylation, thus avoiding the formation of insoluble aggregates. Loss-of-function mutations in this gene have been associated with Lafora disease, a rare, adult-onset recessive neurodegenerative disease, which results in myoclonus epilepsy and usually results in death several years after the onset of symptoms. The disease is characterized by the accumulation of insoluble particles called Lafora bodies, which are derived from glycogen. [provided by RefSeq, Jan 2018]

Database

Research Area

DATA IMAGES

Anti-Laforin antibody, Internal used in IHC (Paraffin sections) (IHC-P). GTX88479

GTX88479 IHC-P Image

IHC-P analysis of human cerebellum using GTX88479 Laforin antibody, Internal.
Antigen retrieval : citrate buffer pH 6
Dilution : 3.8μg/ml

Anti-Laforin antibody, Internal used in Western Blot (WB). GTX88479

GTX88479 WB Image

WB analysis of human cerebellum lysate using GTX88479 Laforin antibody, Internal.
Dilution : 0.1μg/ml
Loading : 35μg protein in RIPA buffer

REFERENCE

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REVIEW

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SDS
Sodium Azide.pdf
Package List Price ($)
$ 369