*Optimal dilutions/concentrations should be determined by the researcher.
Human Cerebellum shows pixulate staining in the cells of the granular layer.
Not tested in other applications.
The peptide used to generate this antibody is available for purchase (GTX88479-PEP).
This antibody is expected to recognize isoform a (NP_005661.1) only.
Mouse, Rat, Bovine, Dog(>80% identity)
TBS pH7.3, 0.5% BSA
0.02% Sodium azide
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
0.50 mg/ml (Please refer to the vial label for the specific concentration.)
Peptide with sequence C-EATGHTNEMKHTTD, from the internal region of the protein sequence according to NP_005661.1.
Purified by ammonium sulphate precipitation followed by antigen affinity chromatography
For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
EPM2A glucan phosphatase, laforin , EPM2 , MELF
Cytoplasm , Endoplasmic reticulum membrane , Cell membrane , Nucleus
This gene encodes a dual-specificity phosphatase and may be involved in the regulation of glycogen metabolism. The protein acts on complex carbohydrates to prevent glycogen hyperphosphorylation, thus avoiding the formation of insoluble aggregates. Loss-of-function mutations in this gene have been associated with Lafora disease, a rare, adult-onset recessive neurodegenerative disease, which results in myoclonus epilepsy and usually results in death several years after the onset of symptoms. The disease is characterized by the accumulation of insoluble particles called Lafora bodies, which are derived from glycogen. [provided by RefSeq, Jan 2018]
GTX88479 IHC-P Image
IHC-P analysis of human cerebellum using GTX88479 Laforin antibody, Internal.
Antigen retrieval : citrate buffer pH 6
Dilution : 3.8μg/ml
GTX88479 WB Image
WB analysis of human cerebellum lysate using GTX88479 Laforin antibody, Internal.
Dilution : 0.1μg/ml
Loading : 35μg protein in RIPA buffer