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Langerin antibody [12D6]

Anti-Langerin antibody [12D6] used in IHC (Paraffin sections) (IHC-P). GTX01915

Cat. No. GTX01915

Reference 5

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 12D6

Isotype

 IgG2b

Application

 IHC-P

Reactivity

 Human
Package
500 μl ($729)
See all Langerin products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
IHC-P 1:50

Note :

IHC-P
The recommended fixative is 10% neutral-buffered formalin for paraffin-embedded tissue sections. Heat Induced Epitope Retreival (HIER) was performed in Epitope Retreival Solution pH6.
Not tested in other applications.

Calculated MW

37 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

Tissue culture supernatant

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.

Antigen Species

Human

Immunogen

Prokaryotic recombinant protein of 29 kD corresponding to the external domain of the langerin molecule.

Purification

Unpurified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

CD207 molecule , CLEC4K

Cellular Localization

Membrane

Background

The protein encoded by this gene is expressed only in Langerhans cells which are immature dendritic cells of the epidermis and mucosa. It is localized in the Birbeck granules, organelles present in the cytoplasm of Langerhans cells and consisting of superimposed and zippered membranes. It is a C-type lectin with mannose binding specificity, and it has been proposed that mannose binding by this protein leads to internalization of antigen into Birbeck granules and providing access to a nonclassical antigen-processing pathway. Mutations in this gene result in Birbeck granules deficiency or loss of sugar binding activity. [provided by RefSeq, Aug 2010]

Database

Research Area

DATA IMAGES

Anti-Langerin antibody [12D6] used in IHC (Paraffin sections) (IHC-P). GTX01915

GTX01915 IHC-P Image

IHC-P analysis of human skin tissue using GTX01915 Langerin antibody [12D6].

REFERENCE

Clone Reference

2020; Langerhans cell histiocytosis of an intra-mammary lymph node in an 18-year-old woman
Application : IHC-P
Reactivity : Human
2020; Different methods of cell quantification can lead to different results: a comparison of digital methods using a pilot study of dendritic cells in HIV-positive patients
Application : IHC-P
Reactivity : Human
2019; Desmoplastic melanoma involving head and fingers: diagnostic challenges and clinical characteristics
Application : IHC-P
Reactivity : Human
2019; ALK-positive histiocytosis: an expanded clinicopathologic spectrum and frequent presence of KIF5B-ALK fusion
Application : IHC-P
Reactivity : Human
2019; Langerin staining identifies most littoral cell angiomas but not most other splenic angiomatous lesions
Application : IHC-P
Reactivity : Human
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REVIEW

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Package List Price ($)
$ 729