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Latrophilin 1 antibody

Anti-Latrophilin 1 antibody used in IHC (Paraffin sections) (IHC-P). GTX71123

Cat No. GTX71123

Host

Rabbit

Clonality

Polyclonal

Isotype

IgG

Application

IHC-P

Reactivity

Human, Mouse, Rat, Rabbit, Bovine, Dog, Hamster, Pig, Monkey, Bat
Package
25 μg ($269)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
IHC-P 8 μg/ml
Not tested in other applications.

Calculated MW

163 kDa. ( Note )

Predict Reactivity

Elephant, Gibbon, Gorilla, Lizard, Marmoset, Opossum, Panda, Xenopus, Platypus(>80% identity)

PROPERTIES

Form

Liquid

Buffer

PBS, 0.1% sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.74 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Synthetic 16 amino acid peptide from N-terminal extracellular domain of human LPHN1.

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

adhesion G protein-coupled receptor L1 , ADGRL1 , CIRL1 , CL1 , LEC2 , LPHN1 , adhesion G proteincoupled receptor L1 , Latrophilin-1

Cellular Localization

Cell membrane,Cell projection,Axon,Growth cone,Cell junction,Synapse,Presynaptic cell membrane,Synaptosome

Background

This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. Latrophilin-1 has been shown to recruit the neurotoxin from black widow spider venom, alpha-latrotoxin, to the synapse plasma membrane. Alternative splicing results in multiple variants encoding distinct isoforms.[provided by RefSeq, Oct 2008]

Database

Research Area

DATA IMAGES

Anti-Latrophilin 1 antibody used in IHC (Paraffin sections) (IHC-P). GTX71123

GTX71123 IHC-P Image

IHC-P analysis of human brain, neurons and glia tissue using GTX71123 Latrophilin 1 antibody.
Antigen retrieval : Heat-induced antigen retrieval

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf