GeneTex
United States (US)

Leptin Receptor antibody

GTX37636_20190129_IHC-P_1_19012901_398.jpg
GTX37636_20190129_WB_19012901_831.jpg
GTX37636_20190129_IHC-Fr_19012901_274.jpg
GTX37636_20190129_IHC-P_19012901_799.jpg

Cat No. GTX37636

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB, IHC-P, IHC-Fr
Reactivity Mouse, Rat, Pig
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1:100-1000
IHC-P 1:100-500
IHC-Fr Assay dependent
Not tested in other applications.

Calculated MW

132 kDa. ( Note )
PROPERTIES

Form

Liquid

Buffer

10 mM PBS, 0.02% sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20º C or below. Avoid multiple freeze-thaw cycles.

Concentration

0.5 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

KLH conjugated synthetic peptide derived from human Leptin Receptor. Please contact us for the exact immunogen sequence.

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Leptin Receptor,Cd295,Lep-R,Leprd,Ob-R,Obr,Lepr

Cellular Localization

Basolateral cell membrane,Cell membrane,Secreted

Background

The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons, however, encode distinct proteins (PMID:9207021).[provided by RefSeq, Nov 2010]

Database

Research Area

DATA IMAGES
GTX37636_20190129_IHC-P_1_19012901_398.jpg

GTX37636 IHC-P Image

IHC-P analysis of rat liver tissue using GTX37636 Leptin Receptor antibody.
Dilution : 2.5μg/ml

GTX37636_20190129_WB_19012901_831.jpg

GTX37636 WB Image

WB analysis of rat small intestines (Lane 1),mouse brain (Lane 2), rat bladder (Lane 3), rat ovary (Lane 4) tissue lysates using GTX37636 Leptin Receptor antibody.
Dilution : 1μg/ml

GTX37636_20190129_IHC-Fr_19012901_274.jpg

GTX37636 IHC-Fr Image

IHC-Fr analysis of pig small intestines tissue using GTX37636 Leptin Receptor antibody.
Dilution : 2.5μg/ml

GTX37636_20190129_IHC-P_19012901_799.jpg

GTX37636 IHC-P Image

IHC-P analysis of pig small intestines tissue using GTX37636 Leptin Receptor antibody.
Dilution : 2.5μg/ml

REFERENCE