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Low Density LRP antibody [8G1]

Cat. No. GTX40384

Reference 3

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 8G1

Isotype

 IgG1

Application

 WB, IHC-P, IHC-Fr, FACS

Reactivity

 Human
Package
100 μg ($399)
See all LRP1 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1-5 μg/ml
IHC-P 1-10 μg/ml
IHC-Fr 1-10 μg/ml
FACS Assay dependent

Note :

WB
using non-reducing conditions

FACS
Recognize an epitope on the extracellular domain
Not tested in other applications.

Calculated MW

505 kDa. ( Note )

Product Note

Specifically reacts with the 515 kDa alpha-chain of human LRP/alpha2 MR expressed in certain cell types. A strongimmunohistochemical reaction is seen in hepatocytes, tissue macrophages, subsets of neurons and astrocytes in theCNS, fibroblasts, smooth muscle cells and monocyte-derived foam cells in atherosclerotic lesions of arterial walls.Will block a2M binding.

PROPERTIES

Form

Liquid

Buffer

0.05M Sodium Phosphate pH7.4, 0.15M Sodium Chloride

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

2.10 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Human LRP/alpha2 MR

Purification

Protein A purified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

LDL receptor related protein 1 , A2MR , APOER , APR , CD91 , IGFBP-3R , IGFBP3R , IGFBP3R1 , KPA , LRP , LRP1A , TGFBR5

Cellular Localization

Nucleus

Background

This gene encodes a member of the low-density lipoprotein receptor family of proteins. The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712). This receptor is involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the alpha 2-macroglobulin-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer's disease patients. [provided by RefSeq, Oct 2015]

Database

Research Area

REFERENCE

Clone Reference

Sivasoorian SS et al. Pharmaceutics 2022; 14 (9) Neuropeptide-Functionalized Gold Nanorod Enhanced Cellular Uptake and Improved In Vitro Photothermal Killing in LRP1-Positive Glioma Cells.
Boel NM et al. Sci Rep 2018; 8 (1):11438 LRP1 is required for novobiocin-mediated fibronectin turnover.
Leone P et al. Blood 2015; 126 (12):1443-51 Dendritic cells accumulate in the bone marrow of myeloma patients where they protect tumor plasma cells from CD8+ T-cell killing.
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Package List Price ($)
$ 399