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M-CSF Receptor antibody [2-4A5-4]

Cat. No. GTX03344

Host

 Rat

Clonality

 Monoclonal

Clone Name

 2-4A5-4

Isotype

 IgG1

Application

 IHC-P, FACS, Functional Assay, Neutralizing/Inhibition

Reactivity

 Human
Package
500 μg ($399)
See all M-CSF Receptor products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
IHC-P Assay dependent
FACS Assay dependent
Functional Assay Assay dependent
Neutralizing/Inhibition Assay dependent
Not tested in other applications.

Calculated MW

108 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

0.2μm-filtered PBS pH7.0

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.

Concentration

4-11 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Rat NRK cells expressing transduced human M-CSF Receptor.

Purification

Protein G purified
From tissue culture supernatant

Purity

>95% by SDS-PAGE

Endotoxin

< 0.002 EU/弮g (Determined by LAL assay)

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

colony stimulating factor 1 receptor , C-FMS , CD115 , CSF-1R , CSFR , FIM2 , FMS , HDLS , M-CSF-R

Cellular Localization

Cell membrane; Single-pass type I membrane protein

Background

The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. Alternative splicing results in multiple transcript variants. Expression of a splice variant from an LTR promoter has been found in Hodgkin lymphoma (HL), HL cell lines and anaplastic large cell lymphoma. [provided by RefSeq, Mar 2017]

Database

Research Area

REFERENCE

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REVIEW

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Package List Price ($)
$ 399
Custom Conjugations