GeneTex
United States (US)

M-CSF Receptor antibody [AFS98]

Cat No. GTX14566

Host Rat
Clonality Monoclonal
Clone Name AFS98
Isotype IgG2a
Application WB, FACS, Functional Assay, Depletion, Neut
Reactivity Mouse
APPLICATION

Application Note

In vivo macrophage depletion, in vitro CSF-R1 neutralization, in vivo monocyte depletion. Endotoxin level : <2EU/mg (<0.002EU/μg) as determined by the LAL gel clotting test.

Calculated MW

108 kDa. ( Note )
PROPERTIES

Form

Liquid

Buffer

PBS, pH 7

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Purification

Protein G. The Purity is >95% as determined by SDS-PAGE.

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Colony Stimulating Factor 1 Receptor,C-Fms,Cd115,Csf-1R,Csfr,Fim2,Fms,Hdls,M-Csf-R,Csf1R

Background

The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. [provided by RefSeq, Jul 2008]

Database

Research Area

REFERENCE
Package List Price ($)
$ 319