APPLICATION
Application Note
WB: 1:500-1:1000, IHC-P: 1:50-1:200
Calculated MW
Product Note
c-Fms (Q718) pAb detects endogenous levels of c-Fms protein.
PROPERTIES
Form
Liquid
Buffer
PBS
Preservative
0.05% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
1 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
Synthetic peptide, corresponding to amino acids 691-740 of Human c-Fms.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
colony stimulating factor 1 receptor , C-FMS , CD115 , CSF-1R , CSFR , FIM2 , FMS , HDLS , M-CSF-R
Cellular Localization
Cell membrane; Single-pass type I membrane protein
Background
The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. Alternative splicing results in multiple transcript variants. Expression of a splice variant from an LTR promoter has been found in Hodgkin lymphoma (HL), HL cell lines and anaplastic large cell lymphoma. [provided by RefSeq, Mar 2017]
Database
Research Area
DATA IMAGES
|
GTX34385 IHC-P Image
Immunohistochemistry (IHC) analyzes of c-Fms pAb in paraffin-embedded human colorectal carcinoma tissue at 1:50.
|
|
|
GTX34385 WB Image
Western blot (WB) analysis of c-Fms pAb at 1:500 dilution Lane1:Hela cell lysate Lane2:sp2/0 cell lysate Lane3:PC12 cell lysate
|
REFERENCE
There are currently no references for M-CSF Receptor antibody (GTX34385). Be the first to share your publications with this product.
REVIEW
There are currently no reviews for M-CSF Receptor antibody (GTX34385). Be the first to share your experience with this product.
