GeneTex
United States (US)

M-CSF Receptor antibody

GTX34385_20170303_IHC-P_18121410_755.jpg
GTX34385_20170303_WB_18121410_575.jpg

Cat No. GTX34385

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB, IHC-P
Reactivity Human, Mouse, Rat
APPLICATION

Application Note

WB: 1:500-1:1000, IHC-P: 1:50-1:200

Calculated MW

108 kDa. ( Note )

Specificity/Sensitivity

c-Fms (Q718) pAb detects endogenous levels of c-Fms protein.
PROPERTIES

Form

Liquid

Buffer

Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Synthetic peptide, corresponding to amino acids 691-740 of Human c-Fms.

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Colony Stimulating Factor 1 Receptor,C-Fms,Cd115,Csf-1R,Csfr,Fim2,Fms,Hdls,M-Csf-R,Csf1R

Background

The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

Database

Research Area

DATA IMAGES
GTX34385_20170303_IHC-P_18121410_755.jpg

GTX34385 IHC-P Image

Immunohistochemistry (IHC) analyzes of c-Fms pAb in paraffin-embedded human colorectal carcinoma tissue at 1:50.

GTX34385_20170303_WB_18121410_575.jpg

GTX34385 WB Image

Western blot (WB) analysis of c-Fms pAb at 1:500 dilution Lane1:Hela cell lysate Lane2:sp2/0 cell lysate Lane3:PC12 cell lysate

Package List Price ($)
$ 339