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MALT1 antibody [MT1/410]

Anti-MALT1 antibody [MT1/410] used in Western Blot (WB). GTX34812
Anti-MALT1 antibody [MT1/410] used in IHC (Paraffin sections) (IHC-P). GTX34812

Cat No. GTX34812

Host Mouse
Clonality Monoclonal
Clone Name MT1/410
Isotype IgG1
Application WB, ICC/IF, IHC-P
Reactivity Human
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 0.5-1ug/ml
ICC/IF 1-2ug/ml
IHC-P 0.5-1ug/ml for 30 minutes at RT

Note :

IHC-P
Boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes

Not tested in other applications.

Calculated MW

92 kDa. ( Note )

Specificity/Sensitivity

Mucosa associated lymphoid tissue lymphoma translocation gene 1 (MALT1) is found in extranodal low-grade B cell lymphomas. MALT1 encodes two Ig-like C2-type domains and fuses with an API2 gene, which is highly expressed in adult lymphoid tissue. The translocation of this MALT1 gene, which maps to human chromosome 18q21, and the apoptosis-inhibiting API2 gene results in an increased development of MALT lymphomas and apoptosis inhibition. Sites at which this API2-MALT1 (11;18)(q21;q21) translocation commonly occurs are within human lung and kidney tissue. MALT lymphoma expresses nuclear Bcl10, which mediates the oligomerization and activation of a MALT1 caspase-like domain. MALT1 mRNA is found in pre-B cells, mature B cells and plasma cells.
PROPERTIES

Form

Liquid

Buffer

Prepared in 10mM PBS with 0.05% BSA and 0.05% azide.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

Human MALT1 recombinant fragment (aa701-808)

Purification

Ab purified from Bioreactor Concentrate by Protein A/G

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Malt1 Paracaspase,Imd12,Mlt,Mlt1,Pcasp1,Malt1

Background

This gene has been found to be recurrently rearranged in chromosomal translocation with two other genes - baculoviral IAP repeat-containing protein 3 (also known as apoptosis inhibitor 2) and immunoglobulin heavy chain locus - in mucosa-associated lymphoid tissue lymphomas. The protein encoded by this gene may play a role in NF-kappaB activation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES
Anti-MALT1 antibody [MT1/410] used in Western Blot (WB). GTX34812

GTX34812 WB Image

Western Blot Analysis of Daudi Cell Lysate using MALT1 Monoclonal Antibody (MT1/410)

Anti-MALT1 antibody [MT1/410] used in IHC (Paraffin sections) (IHC-P). GTX34812

GTX34812 IHC-P Image

Formalin-fixed, paraffin-embedded human Tonsil stained with MALT1 Monoclonal Antibody (MT1/410)

Package List Price ($)
$ 329