APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| 1-2μg/ml |
| 1-2μg/ml |
| 1-2μg/ml for 30 minutes at RT |
| 1-2μg/10⁶ cells |
|
Note :
IHC-P
Staining of formalin-fixed tissues is enhanced by heating tissue sections in 10mM Tris buffer with 1mM EDTA, pH 9.0, for 45 min at 95ºC followed by cooling at RT for 20 minutes.
|
Not tested in other applications.
Calculated MW
PROPERTIES
Form
Liquid
Buffer
10mM PBS, 0.05% BSA
Preservative
0.05% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
0.2 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
Recombinant human MAML2 fragment
Purification
Protein A/G purified
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
MAM2 , MAM3 , MAML2 , MLLMAML2 , mastermind like transcriptional coactivator 2
Cellular Localization
Nucleus speckle
Background
The protein encoded by this gene is a member of the Mastermind-like family of proteins. All family members are proline and glutamine-rich, and contain a conserved basic domain that binds the ankyrin repeat domain of the intracellular domain of the Notch receptors (ICN1-4) in their N-terminus, and a transcriptional activation domain in their C-terminus. This protein binds to an extended groove that is formed by the interaction of CBF1, Suppressor of Hairless, LAG-1 (CSL) with ICN, and positively regulates Notch signaling. High levels of expression of this gene have been observed in several B cell-derived lymphomas. Translocations resulting in fusion proteins with both CRTC1 and CRTC3 have been implicated in the development of mucoepidermoid carcinomas, while a translocation event with CXCR4 has been linked with chronic lymphocytic leukemia (CLL). Copy number variation in the polyglutamine tract has been observed. [provided by RefSeq, Jan 2015]
Database
Research Area
DATA IMAGES
![Anti-MAML2 antibody [MAML2/1302] used in IHC (Paraffin sections) (IHC-P). GTX34814](/templates/default/js/lightbox/images/loading.gif "Anti-MAML2 antibody [MAML2/1302] used in IHC (Paraffin sections) (IHC-P). GTX34814")
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GTX34814 IHC-P Image
IHC-P analysis of human pancreas tissue using GTX34814 MAML2 antibody [MAML2/1302].
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GTX34814 IHC-P Image
IHC-P analysis of human bladder carcinoma tissue using GTX34814 MAML2 antibody [MAML2/1302].
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GTX34814 IHC-P Image
IHC-P analysis of human placenta tissue using GTX34814 MAML2 antibody [MAML2/1302].
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GTX34814 IHC-P Image
IHC-P analysis of human colon carcinoma tissue using GTX34814 MAML2 antibody [MAML2/1302].
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REFERENCE
There are currently no references for MAML2 antibody [MAML2/1302] (GTX34814). Be the first to share your publications with this product.
REVIEW
There are currently no reviews for MAML2 antibody [MAML2/1302] (GTX34814). Be the first to share your experience with this product.
![Anti-MAML2 antibody [MAML2/1302] used in IHC (Paraffin sections) (IHC-P). GTX34814](/upload/website/prouct_img/small/GTX34814/GTX34814_20200115_IHC-P_886_w_23060801_380.webp "Anti-MAML2 antibody [MAML2/1302] used in IHC (Paraffin sections) (IHC-P). GTX34814")
![Anti-MAML2 antibody [MAML2/1302] used in IHC (Paraffin sections) (IHC-P). GTX34814](/upload/website/prouct_img/small/GTX34814/GTX34814_20200115_IHC-P_306_w_23060801_546.webp "Anti-MAML2 antibody [MAML2/1302] used in IHC (Paraffin sections) (IHC-P). GTX34814")
![Anti-MAML2 antibody [MAML2/1302] used in IHC (Paraffin sections) (IHC-P). GTX34814](/upload/website/prouct_img/small/GTX34814/GTX34814_20200115_IHC-P_979_w_23060801_692.webp "Anti-MAML2 antibody [MAML2/1302] used in IHC (Paraffin sections) (IHC-P). GTX34814")
![Anti-MAML2 antibody [MAML2/1302] used in IHC (Paraffin sections) (IHC-P). GTX34814](/upload/website/prouct_img/small/GTX34814/GTX34814_20200115_IHC-P_475_w_23060801_730.webp "Anti-MAML2 antibody [MAML2/1302] used in IHC (Paraffin sections) (IHC-P). GTX34814")
![Anti-MAML2 antibody [MAML2/1302] used in IHC (Paraffin sections) (IHC-P). GTX34814](/upload/website/prouct_img/normal/GTX34814/GTX34814_20200115_IHC-P_886_w_23060801_380.webp "Anti-MAML2 antibody [MAML2/1302] used in IHC (Paraffin sections) (IHC-P). GTX34814")
![Anti-MAML2 antibody [MAML2/1302] used in IHC (Paraffin sections) (IHC-P). GTX34814](/upload/website/prouct_img/normal/GTX34814/GTX34814_20200115_IHC-P_306_w_23060801_546.webp "Anti-MAML2 antibody [MAML2/1302] used in IHC (Paraffin sections) (IHC-P). GTX34814")
![Anti-MAML2 antibody [MAML2/1302] used in IHC (Paraffin sections) (IHC-P). GTX34814](/upload/website/prouct_img/normal/GTX34814/GTX34814_20200115_IHC-P_979_w_23060801_692.webp "Anti-MAML2 antibody [MAML2/1302] used in IHC (Paraffin sections) (IHC-P). GTX34814")
![Anti-MAML2 antibody [MAML2/1302] used in IHC (Paraffin sections) (IHC-P). GTX34814](/upload/website/prouct_img/normal/GTX34814/GTX34814_20200115_IHC-P_475_w_23060801_730.webp "Anti-MAML2 antibody [MAML2/1302] used in IHC (Paraffin sections) (IHC-P). GTX34814")