GeneTex
United States (US)

MAML2 antibody [MAML2/1302]

Anti-MAML2 antibody [MAML2/1302] used in IHC (Paraffin sections) (IHC-P). GTX34814
Anti-MAML2 antibody [MAML2/1302] used in IHC (Paraffin sections) (IHC-P). GTX34814
Anti-MAML2 antibody [MAML2/1302] used in IHC (Paraffin sections) (IHC-P). GTX34814
Anti-MAML2 antibody [MAML2/1302] used in IHC (Paraffin sections) (IHC-P). GTX34814

Cat No. GTX34814

Host Mouse
Clonality Monoclonal
Clone Name MAML2/1302
Isotype IgG2a
Application WB, ICC/IF, IHC-P
Reactivity Human
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 0.5-1ug/ml
ICC/IF 0.5-1ug/ml
IHC-P 0.5-1ug/ml for 30 minutes at RT

Note :

IHC-P
Boiling tissue sections in 10mM Tris with 1mM EDTA, pH 9.0 for 10-20 min followed by cooling at RT for 20 minutes

Not tested in other applications.

Calculated MW

125 kDa. ( Note )

Specificity/Sensitivity

MAML2 (mastermind-like protein 2), also known as MAM2, MAM3 or MLLMAML2, is a nuclear speckle protein that acts as a transcriptional co-activator for Notch receptors. The Notch signaling pathway influences cell fate by regulating the ability of precursor cells to properly respond to developmental signals. MAML2 is a member of the mastermind-like family of proteins that are human homologs of the Drosophila melanogaster mastermind protein. Through its N-terminal region, MAML2 interacts with the ankyrin repeats of the Notch proteins Notch 1, Notch 2, Notch 3 and Notch 4. This interaction leads to formation of a DNA-binding complex with the Notch proteins and RBP-Jκ; a complex that can then induce HES1 gene expression. While the N-terminal domain of MAML2 is essential for proper Notch binding, the C-terminal domain of MAML2 is essential for transcriptional activation. A chromosomal aberration involving the gene encoding MAML2 is implicated in mucoepidermoid carcinomas, clear cell hidradenomas and benign Warthin tumors.
PROPERTIES

Form

Liquid

Buffer

Prepared in 10mM PBS with 0.05% BSA and 0.05% azide.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

Recombinant human full-length MAML2

Purification

Ab purified from Bioreactor Concentrate by Protein A/G

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Mastermind Like Transcriptional Coactivator 2,Mam-3,Mam2,Mam3,Mll-Maml2,Maml2

Database

Research Area

DATA IMAGES
Anti-MAML2 antibody [MAML2/1302] used in IHC (Paraffin sections) (IHC-P). GTX34814

GTX34814 IHC-P Image

Formalin-fixed, paraffin-embedded Human Placenta stained with MAML2 Monoclonal Antibody (MAML2/1302).

Anti-MAML2 antibody [MAML2/1302] used in IHC (Paraffin sections) (IHC-P). GTX34814

GTX34814 IHC-P Image

Formalin-fixed, paraffin-embedded Human Bladder Carcinoma stained with MAML2 Monoclonal Antibody (MAML2/1302).

Anti-MAML2 antibody [MAML2/1302] used in IHC (Paraffin sections) (IHC-P). GTX34814

GTX34814 IHC-P Image

Formalin-fixed, paraffin-embedded Human Pancreas stained with MAML2 Monoclonal Antibody (MAML2/1302).

Anti-MAML2 antibody [MAML2/1302] used in IHC (Paraffin sections) (IHC-P). GTX34814

GTX34814 IHC-P Image

Formalin-fixed, paraffin-embedded Human Colon Carcinoma stained with MAML2 Monoclonal Antibody (MAML2/1302).

Package List Price ($)
$ 329