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MAML3 antibody [MAML3/1303]

Anti-MAML3 antibody [MAML3/1303] used in IHC (Paraffin sections) (IHC-P). GTX34815
Anti-MAML3 antibody [MAML3/1303] used in IHC (Paraffin sections) (IHC-P). GTX34815
Anti-MAML3 antibody [MAML3/1303] used in IHC (Paraffin sections) (IHC-P). GTX34815
Anti-MAML3 antibody [MAML3/1303] used in IHC (Paraffin sections) (IHC-P). GTX34815

Cat No. GTX34815

Host Mouse
Clonality Monoclonal
Clone Name MAML3/1303
Isotype IgG1
Application ICC/IF, IHC-P
Reactivity Human
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
ICC/IF 0.5-1ug/ml
IHC-P 0.5-1ug/ml for 30 minutes at RT

Note :

IHC-P
Boiling tissue sections in 10mM Tris with 1mM EDTA, pH 9.0 for 10-20 min followed by cooling at RT for 20 minutes

Not tested in other applications.

Calculated MW

122 kDa. ( Note )

Specificity/Sensitivity

MAML3 (mastermind-like protein 3) is a nuclear speckle protein that acts as a transcriptional coactivator for Notch receptors. The Notch signaling pathway influences cell fate by regulating the ability of precursor cells to properly respond to developmental signals. MAML3 is a member of the mastermind-like family of proteins that are human homologs of the Drosophila melanogaster mastermind protein. Through its N-terminal region, MAML3 interacts with the ankyrin repeats of the Notch proteins Notch 1, Notch 2, Notch 3 and Notch 4.This interaction leads to formation of a DNA-binding complex with the Notch proteins and RBP-Jκ; a complex that can then induce HES1 gene expression. While the N-terminal domain of MAML3 is essential for proper Notch binding, the C-terminal domain of MAML3 is essential for transcriptional activation. Due to its involvement in cell signaling and transcriptional activation, upregulation of MAML3 is thought to be involved in oncogenesis.
PROPERTIES

Form

Liquid

Buffer

Prepared in 10mM PBS with 0.05% BSA and 0.05% azide.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

Recombinant human full-length MAML3 protein

Purification

Ab purified from Bioreactor Concentrate by Protein A/G

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Mastermind Like Transcriptional Coactivator 3,Cagh3,Erda3,Gdn,Mam-2,Mam2,Tnrc3,Mam-3,Maml3

Database

Research Area

DATA IMAGES
Anti-MAML3 antibody [MAML3/1303] used in IHC (Paraffin sections) (IHC-P). GTX34815

GTX34815 IHC-P Image

Formalin-fixed, paraffin-embedded Human Pancreas stained with MAML3 Monoclonal Antibody (MAML3/1303).

Anti-MAML3 antibody [MAML3/1303] used in IHC (Paraffin sections) (IHC-P). GTX34815

GTX34815 IHC-P Image

Formalin-fixed, paraffin-embedded Human Colon Carcinoma stained with MAML3 Monoclonal Antibody (MAML3/1303).

Anti-MAML3 antibody [MAML3/1303] used in IHC (Paraffin sections) (IHC-P). GTX34815

GTX34815 IHC-P Image

Formalin-fixed, paraffin-embedded Human Cervical Carcinoma stained with MAML3 Monoclonal Antibody (MAML3/1303).

Anti-MAML3 antibody [MAML3/1303] used in IHC (Paraffin sections) (IHC-P). GTX34815

GTX34815 IHC-P Image

Formalin-fixed, paraffin-embedded Human Placenta stained with MAML3 Monoclonal Antibody (MAML3/1303).

Package List Price ($)
$ 329