Phosphate-buffered saline, pH 7.4 containing 0.02% sodium azide
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
0.5 mg/ml (Please refer to the vial label for the specific concentration.)
Synthetic peptide - amino acids 931-947 of Human NIK
Affinity purified with antigen
For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Mitogen-Activated Protein Kinase Kinase Kinase 14,Ftdcr1B,Hs,Hsnik,Nik,Map3K14
Nuclear factor kappa B (NF-kB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-kB mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNFa, LPS and mitogens. A serine/threonine protein kinase, which mediates NF-kB activation by IL-1, TNFa and CD95, was identified recently and designated NIK (for NF-kB inducing kinase)(1). NIK is an activator of IkB kinase alpha and beta (IKKa and IKKb) (2-5). Therefore, NIK is a key molecule in the NF-kB signaling pathway leading to the induction of a variety of gene expression in response to pro-inflammatory cytokines and bacteria products.