GeneTex
United States (US)

MAP3K14 antibody

NFkB-antibody-GTX28111-IHC-1_18121411_419.jpg

Cat No. GTX28111

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB, IHC
Reactivity Human
APPLICATION

Application Note

For WB: Use at a dilution of 1:500. Optimal dilutions/concentrations should be determined by the researcher.

Calculated MW

104 kDa. ( Note )

Positive Control

293 whole cell lysate
PROPERTIES

Form

Liquid

Buffer

Phosphate-buffered saline, pH 7.4 containing 0.02% sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.5 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Synthetic peptide - amino acids 931-947 of Human NIK

Purification

Affinity purified with antigen

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Mitogen-Activated Protein Kinase Kinase Kinase 14,Ftdcr1B,Hs,Hsnik,Nik,Map3K14

Background

Nuclear factor kappa B (NF-kB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-kB mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNFa, LPS and mitogens. A serine/threonine protein kinase, which mediates NF-kB activation by IL-1, TNFa and CD95, was identified recently and designated NIK (for NF-kB inducing kinase)(1). NIK is an activator of IkB kinase alpha and beta (IKKa and IKKb) (2-5). Therefore, NIK is a key molecule in the NF-kB signaling pathway leading to the induction of a variety of gene expression in response to pro-inflammatory cytokines and bacteria products.

Database

DATA IMAGES
NFkB-antibody-GTX28111-IHC-1_18121411_419.jpg

GTX28111 IHC Image


Package List Price ($)
$ 329