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MCL1 antibody

Anti-MCL1 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX31709
Anti-MCL1 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX31709
Anti-MCL1 antibody used in Western Blot (WB). GTX31709

Cat No. GTX31709

Host

Rabbit

Clonality

Polyclonal

Isotype

IgG

Application

WB, ICC/IF, ELISA

Reactivity

Human
Package
100 μg ($339)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1 - 2 μg/mL
ICC/IF 10 μg/mL
ELISA Assay dependent
Not tested in other applications.

Calculated MW

37 kDa. ( Note )

Positive Control

Raji Cell Slide(GTX25538) , Raji Cell Lysate(GTX27908)

Specificity/Sensitivity

Detects isoforms Mcl-1L and Mcl-1S

PROPERTIES

Form

Liquid

Buffer

PBS with 0.02% sodium azide.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Mcl-1 antibody was raised against a peptide corresponding to 16 amino acids near the amino-terminus of human Mcl-1.The immunogen is located within amino acids 20 - 70 of Mcl-1.

Purification

Purified by ion exchange chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

MCL1 apoptosis regulator, BCL2 family member , BCL2L3 , EAT , MCL1-ES , MCL1L , MCL1S , Mcl-1 , TM , bcl2-L-3 , mcl1/EAT

Cellular Localization

Membrane,Cytoplasm,Mitochondrion,nucleoplasm

Background

This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing. [provided by RefSeq, Oct 2010]

Database

Research Area

DATA IMAGES

Anti-MCL1 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX31709

GTX31709 ICC/IF Image

ICC/IF analysis of Raji cells using GTX31709 MCL1 antibody.
Working concentration : 10 μg/ml

Anti-MCL1 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX31709

GTX31709 ICC/IF Image

ICC/IF analysis of Raji cells using GTX31709 MCL1 antibody.
Working concentration : 20 μg/ml

Anti-MCL1 antibody used in Western Blot (WB). GTX31709

GTX31709 WB Image

WB analysis of Raji cell lysate using GTX31709 MCL1 antibody.
Working concentration : (A) 1 and (B) 2 μg/ml

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 339