GeneTex
United States (US)

MCM7 antibody [MCM7/1467]

GTX34818_20170712_IHC-P_18121410_466.jpg

Cat No. GTX34818

Host Mouse
Clonality Monoclonal
Clone Name MCM7/1467
Isotype IgG2a
Application IHC-P
Reactivity Human
APPLICATION

Application Note

IHC-P:1-2ug/ml for 30 minutes at RT.

Calculated MW

81 kDa. ( Note )

Specificity/Sensitivity

MCM7 is one of the highly conserved mini-chromosome maintenance proteins (MCM) that is essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumor suppressor protein RB1/RB.
PROPERTIES

Form

Liquid

Buffer

Prepared in 10mM PBS with 0.05% BSA and 0.05% azide.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

Recombinant human MCM7 protein fragment (aa195-319) (exact sequence is proprietary)

Purification

Ab purified from Bioreactor Concentrate by Protein A/G

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Minichromosome Maintenance Complex Component 7,Cdc47,Mcm2,P1.1-Mcm3,P1Cdc47,P85Mcm,Pnas146,Ppp1R104,Mcm7

Background

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES
GTX34818_20170712_IHC-P_18121410_466.jpg

GTX34818 IHC-P Image

Formalin-fixed, paraffin-embedded human Tonsil stained with MCM7 Monoclonal Antibody (MCM7/1467).

Package List Price ($)
$ 329