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MD1 antibody

Anti-MD1 antibody used in Western Blot (WB). GTX85065
Anti-MD1 antibody used in IHC (Paraffin sections) (IHC-P). GTX85065

Cat. No. GTX85065

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC-P, ELISA

Reactivity

 Human, Mouse, Rat
Package
100 μg ($399)
See all MD1 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1 - 2 μg/mL
IHC-P 2.5 μg/mL
ELISA Assay dependent
Not tested in other applications.

Calculated MW

18 kDa. ( Note )

Positive Control

Daudi Cell Lysate(GTX23951) , Human Spleen Tissue Lysate(GTX27921) , Human Spleen Tissue Slide

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

MD-1 antibody was raised against a 15 amino acid synthetic peptide from near the center of human MD-1.The immunogen is located within the last 50 amino acids of MD-1.

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

lymphocyte antigen 86 , MD-1 , MD1 , MMD-1 , dJ80N2.1

Background

Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. The signaling of these TLRs is kept under tight control by the expression of endogenous inhibiting proteins such as RP105, a recently identified homolog of TLR4. This protein, in association with MD-1, interacts with and inhibits the TLR4/MD-2 signaling pathway. While MD-2 can directly bind to LPS, one of the activating molecules of TLR4, the function of MD-1 is less well-known. It has been suggested however, that the RP105/MD-1 complex influences antibody production mediated by both TLR4/MD-2 and TLR2 receptor complexes.

Database

Research Area

DATA IMAGES

Anti-MD1 antibody used in Western Blot (WB). GTX85065

GTX85065 WB Image

WB analysis of Daudi cell lysate using GTX85065 MD1 antibody.
Working concentration : (A) 1 and (B) 2 μg/ml

Anti-MD1 antibody used in IHC (Paraffin sections) (IHC-P). GTX85065

GTX85065 IHC-P Image

IHC-P analysis of human spleen tissue using GTX85065 MD1 antibody.
Working concentration : 2.5 μg/ml

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399