GeneTex
United States (US)

MEK2 antibody [2C3]

Anti-MEK2 antibody [2C3] used in Western Blot (WB). GTX34070

Cat No. GTX34070

Host Mouse
Clonality Monoclonal
Clone Name 2C3
Isotype IgG1
Application WB
Reactivity Human, Mouse, Rat
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB Assay dependent
Not tested in other applications.

Calculated MW

44 kDa. ( Note )

Specificity/Sensitivity

MEK2 Mouse Monoclonal Antibody (2C3) detects endogenous levels of MEK2
PROPERTIES

Form

Liquid

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

Synthesized peptide derived from human MEK-2 around the non-phosphorylation site of T394.

Purification

The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Mitogen-Activated Protein Kinase Kinase 2,Cfc4,Mapkk2,Mek2,Mkk2,Prkmk2,Map2K2

Background

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES
Anti-MEK2 antibody [2C3] used in Western Blot (WB). GTX34070

GTX34070 WB Image

Western Blot (WB) analysis of 1) HeLa, 2)3T3, 3) Rat Brain Tissue with MEK2 Mouse Monoclonal Antibody diluted at 1:2000.

Package List Price ($)
$ 319