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MEK2 antibody

KO/KD
Anti-MEK2 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX35223
Anti-MEK2 antibody used in Western Blot (WB). GTX35223
Anti-MEK2 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX35223
Anti-MEK2 antibody used in Western Blot (WB). GTX35223

Cat. No. GTX35223

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, ICC/IF

Reactivity

 Human, Mouse
Package
100 μl ($399)
See all MEK2 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:500 - 1:2000
ICC/IF 1:50 - 1:200
Not tested in other applications.

Calculated MW

44 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS, 50% Glycerol

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 1-100 of human MAP2K2 (NP_109587.1).

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

mitogen-activated protein kinase kinase 2 , CFC4 , MAPKK2 , MEK2 , MKK2 , PRKMK2

Cellular Localization

Cytoplasm,Membrane

Background

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, cognitive disability, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-MEK2 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX35223

GTX35223 ICC/IF Image

ICC/IF analysis of U2OS cells using GTX35223 MEK2 antibody.
Blue : DAPI
Dilution : 1:100

Anti-MEK2 antibody used in Western Blot (WB). GTX35223

GTX35223 WB Image

WB analysis of HeLa cell lysate using GTX35223 MEK2 antibody.
Dilution : 1:1000
Loading : 25μg per lane

Anti-MEK2 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX35223

GTX35223 ICC/IF Image

ICC/IF analysis of NIH/3T3 cells using GTX35223 MEK2 antibody.
Blue : DAPI
Dilution : 1:100

Anti-MEK2 antibody used in Western Blot (WB). GTX35223

GTX35223 WB Image

KO/KD

WB analysis of normal (control) and knockout (KO) 293T cell lysate using GTX35223 MEK2 antibody.
Dilution : 1:1000
Loading : 25μg per lane

REFERENCE

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REVIEW

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SDS
PBS.pdf
Glycerol.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399