Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
0.65-1.25 mg/ml (Please refer to the vial label for the specific concentration.)
Synthetic peptide (Human).
Immunogen affinity purified
For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Mer Proto-Oncogene, Tyrosine Kinase,Mer,Rp38,Tyro12,C-Eyk,C-Mer,Mertk
In vertebrates, the photoreceptor cells are the basic sensory apparatus of the retina primarily converting photon energy absorbed from light into neuronal signals. The photoreceptor proximal outer segments are synthesized daily by cell bodies, and outer segment tips are removed with a circadian rhythm. The shed outer segments are endocytosed by adjacent retinal pigment epithelial (RPE) cells, and are recycled to photoreceptors. The receptor tyrosine kinase MERTK protein is a approximately 120-122 kDa (994 amino acids) protein expressed in RPEs. MERTK has a tyrosine kinase domain closer to the C-terminal region and putative phosphorylation sites. Mutation of MERTK in the Royal College of Surgeons (RCS) rat results in defective phagocytosis of photoreceptor outer segments by the retinal pigment epithelium (RPE) and retinal degeneration resulting in retinitis pigmentosa.