GeneTex
United States (US)

MERTK antibody

MERTK-antibody_WB_GTX14919-1_18121411_434.jpg

Cat No. GTX14919

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB, ICC/IF, IP
Reactivity Human
APPLICATION

Application Note

ICC: Use at an assay dependent dilution. IP: Use at a dilution of 1/200. WB: Use at a dilution of 1/500. Detects a band of approximately 110 kDa. Optimal dilutions/concentrations should be determined by the end user.

Calculated MW

110 kDa. ( Note )
PROPERTIES

Form

Liquid

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.65-1.25 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Synthetic peptide (Human).

Purification

Immunogen affinity purified

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Mer Proto-Oncogene, Tyrosine Kinase,Mer,Rp38,Tyro12,C-Eyk,C-Mer,Mertk

Background

In vertebrates, the photoreceptor cells are the basic sensory apparatus of the retina primarily converting photon energy absorbed from light into neuronal signals. The photoreceptor proximal outer segments are synthesized daily by cell bodies, and outer segment tips are removed with a circadian rhythm. The shed outer segments are endocytosed by adjacent retinal pigment epithelial (RPE) cells, and are recycled to photoreceptors. The receptor tyrosine kinase MERTK protein is a approximately 120-122 kDa (994 amino acids) protein expressed in RPEs. MERTK has a tyrosine kinase domain closer to the C-terminal region and putative phosphorylation sites. Mutation of MERTK in the Royal College of Surgeons (RCS) rat results in defective phagocytosis of photoreceptor outer segments by the retinal pigment epithelium (RPE) and retinal degeneration resulting in retinitis pigmentosa.

Database

Research Area

DATA IMAGES
MERTK-antibody_WB_GTX14919-1_18121411_434.jpg

GTX14919 WB Image

Western blot using GTX14919 and human RPE cells (antibody dilution 1:500).

Package List Price ($)
$ 359