APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| 1 - 2 μg/mL |
| 5 μg/mL |
| Assay dependent |
Not tested in other applications.
Calculated MW
Positive Control
Rat Lung Tissue Lysate(GTX27941)
PROPERTIES
Form
Liquid
Buffer
PBS
Preservative
0.02% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
1 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
MFSD2A antibody was raised against an 18 amino acid synthetic peptide near the carboxy terminus of human MFSD2A.The immunogen is located within the last 50 amino acids of MFSD2A.
Purification
Purified by antigen-affinity chromatography
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
major facilitator superfamily domain containing 2A , MCPH15 , MFSD2 , NLS1
Cellular Localization
Cell membrane,Endoplasmic reticulum membrane
Background
Multidrug transporters, such as MFSD2A, are membrane proteins that expel a wide spectrum of cytotoxic compounds from the cell and render cells resistant to multiple drugs. Major Facilitator Superfamily (MFS) members are capable of transporting various substrates such as sugars, polyols, drugs, neurotransmitters, amino acids, peptides, and inorganic anions, although most members are substrate-specific. MFSD2A is a novel lung cancer tumor suppressor gene that regulates cell cycle progression and matrix attachment and has recently been described as the human receptor for syncytin-2, a retrovirus-derived protein mediating fusion of placental trophoblasts. MFSD2A is expressed in many tissues and is highly induced in liver and brown adipose tissue (BAT) during fasting. The activation of the betaAR signaling pathway plays a major role in the induction of MFSD2A expression during adaptive thermogenesis.
Database
Research Area
DATA IMAGES
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GTX85147 IHC-P Image
IHC-P analysis of human brain tissue using GTX85147 MFSD2A antibody.
Dilution : 5 μg/ml
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GTX85147 WB Image
WB analysis of rat lung tissue lysate using GTX85147 MFSD2A antibody.
Working concentration : (A) 1 and (B) 2 μg/ml
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GTX85147 IHC-P Image
IHC-P analysis of rat lung tissue using GTX85147 MFSD2A antibody.
Working concentration : 5 μg/ml
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GTX85147 IHC-P Image
IHC-P analysis of mouse lung tissue using GTX85147 MFSD2A antibody.
Working concentration : 2.5 μg/ml
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GTX85147 IHC-P Image
IHC-P analysis of rat lung tissue using GTX85147 MFSD2A antibody.
Working concentration : 20 μg/ml
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GTX85147 IHC-P Image
IHC-P analysis of mouse lung tissue using GTX85147 MFSD2A antibody.
Red : Primary antibody
Blue : DAPI
Dilution : 20 μg/ml
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REFERENCE
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REVIEW
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