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MIP1 alpha antibody

Anti-MIP1 alpha antibody used in IHC (Paraffin sections) (IHC-P). GTX52609

Cat No. GTX52609

Host

Rabbit

Clonality

Polyclonal

Isotype

IgG

Application

IHC-P

Reactivity

Human
Package
500 μl ($319)

APPLICATION

Application Note

Recommended dilutions: IHC-P: 1/50 for 30 minutes at room temperature. Perform heat mediated antigen retrieval before commencing with IHC staining protocol. Not yet tested in other applications. Optimal dilutions/concentrations should be determined by the end user.

Calculated MW

10 kDa. ( Note )

Positive Control

Lung carcinoma

PROPERTIES

Form

Liquid

Buffer

Phosphate-buffered saline, pH 7.4 containing 1% BSA and 0.09% sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Synthetic peptide: EEW VQKYVSDLEL SA , corresponding to C terminal amino acids 77-92 of Human Macrophage Inflammatory Protein 1 alpha / CCL3

Purification

Immunogen affinity purified

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

C-C Motif Chemokine Ligand 3 , G0S19-1 , Ld78Alpha , Mip-1-Alpha , Mip1A , Scya3 , Ccl3

Cellular Localization

Secreted

Background

Macrophage Inflammatory Protein 1 alpha (MIP1 alpha) and MIP1 beta, two closely related but distinct proteins, were originally co-purified from medium conditioned by a LPS-stimulated murine macrophage cell line. Mature mouse MIP1 alpha shares approximately 77% and 70% amino acid identity with human MIP1 alpha and mouse MIP1 beta, respectively. MIP1 proteins are expressed primarily in T cells, B cells, and monocytes after antigen or mitogen stimulation. Has adhesive effects on lymphocytes. MIP1 alpha can inhibit the proliferation of hematopoietic stem cells in vitro as well as in vivo. A signal transducing receptor, designated the C-C chemokine receptor-1 (C-C CKR-1) with seven transmembrane domains that bind MIP1 alpha, MIP1 beta, MCP1 and RANTES with varying affinities, has been isolated.

Database

Research Area

DATA IMAGES

Anti-MIP1 alpha antibody used in IHC (Paraffin sections) (IHC-P). GTX52609

GTX52609 IHC-P Image

Human Lung stained with anti-MIP-1 alpha antibody

REFERENCE

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REVIEW

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SDS
Sodium Azide.pdf
Package List Price ($)
$ 319