GeneTex

  • Country / Location Selection

United States (US)

MITF antibody [C5 + D5]

Cat. No. GTX01743

Reference 6

Host

 Mouse

Clonality

 Multiclonal

Clone Name

 C5 + D5

Isotype

 IgG1

Application

 WB, ICC/IF, IHC-P, ChIP assay

Reactivity

 Human, Mouse
Package
500 μl ($399)
See all MITF products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB Assay dependent
ICC/IF Assay dependent
IHC-P 1:50-1:200
ChIP assay Assay dependent

Note :

IHC-P
Pretreatment of deparaffinized tissue with heat-induced epitope retrieval or enzymatic retrieval is recommended.
Not tested in other applications.

Calculated MW

59 kDa. ( Note )

Positive Control

Melanoma

PROPERTIES

Form

Liquid

Buffer

Tris-HCl, 0.2% BSA

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

N-terminal fragment of human Mi protein

Purification

Purified IgG

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

melanocyte inducing transcription factor , CMM8 , COMMAD , MI , WS2 , WS2A , bHLHe32

Cellular Localization

Nucleus

Background

The protein encoded by this gene is a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. The encoded protein regulates melanocyte development and is responsible for pigment cell-specific transcription of the melanogenesis enzyme genes. Heterozygous mutations in the this gene cause auditory-pigmentary syndromes, such as Waardenburg syndrome type 2 and Tietz syndrome. [provided by RefSeq, Aug 2017]

Database

Research Area

REFERENCE

Clone Reference

2019; Is melanocyte density our last hope? Comparison of histologic features of photodamaged skin and melanoma in situ after staged surgical excision with concurrent scouting biopsies
Application : IHC-P
Reactivity : Human
2019; Pulmonary melanocytic nevus - A case report with a mutation analysis of common driver oncogenes
Application : IHC-P
Reactivity : Human
2018; Immunohistochemical expression of melanocytic and myofibroblastic markers and their molecular correlation in atypical fibroxanthomas and pleomorphic dermal sarcomas
Reactivity : Human
2018; New observations in tumor cell plasticity: mutational profiling in a case of metastatic melanoma with biphasic sarcomatoid transdifferentiation
Application : IHC-P
Reactivity : Human
2007; VMD2 promoter requires two proximal E-box sites for its activity in vivo and is regulated by the MITF-TFE family
Application : ChIP assay
Reactivity : Human
Show More +
Submit a Reference

REVIEW

There are currently no reviews for MITF antibody [C5 + D5] (GTX01743). Be the first to share your experience with this product.
Submit a Review
Package List Price ($)
$ 399