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MLH1 antibody [ES05]

Anti-MLH1 antibody [ES05] used in IHC (Paraffin sections) (IHC-P). GTX01906

Cat No. GTX01906

Host

Mouse

Clonality

Monoclonal

Clone Name

ES05

Isotype

IgG1

Application

IHC-P

Reactivity

Human
Package
500 μl ($719)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
IHC-P 1:50

Note :

IHC-P
The recommended fixative is 10% neutral-buffered formalin for paraffin-embedded tissue sections.

Not tested in other applications.

Calculated MW

85 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

Tissue culture supernatant, 15 mM sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.

Concentration

>165 μg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Prokaryotic recombinant protein corresponding to 210 amino acids of human MLH1.

Purification

Unpurified

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

mutL homolog 1 , COCA2 , FCC2 , HNPCC , HNPCC2 , hMLH1

Cellular Localization

Nucleus

Background

The protein encoded by this gene can heterodimerize with mismatch repair endonuclease PMS2 to form MutL alpha, part of the DNA mismatch repair system. When MutL alpha is bound by MutS beta and some accessory proteins, the PMS2 subunit of MutL alpha introduces a single-strand break near DNA mismatches, providing an entry point for exonuclease degradation. The encoded protein is also involved in DNA damage signaling and can heterodimerize with DNA mismatch repair protein MLH3 to form MutL gamma, which is involved in meiosis. This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). [provided by RefSeq, Aug 2017]

Database

Research Area

DATA IMAGES

Anti-MLH1 antibody [ES05] used in IHC (Paraffin sections) (IHC-P). GTX01906

GTX01906 IHC-P Image

IHC-P analysis of colorectal carcinoma tissue using GTX01906 MLH1 antibody [ES05]. Note nuclear staining in a high proportion of the malignant cells.

REFERENCE

There are currently no references for MLH1 antibody [ES05] (GTX01906). Be the first to share your publications with this product.

REVIEW

There are currently no reviews for MLH1 antibody [ES05] (GTX01906). Be the first to share your experience with this product.
Package List Price ($)
$ 719