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MLH1 antibody [ES05]

Anti-MLH1 antibody [ES05] used in IHC (Paraffin sections) (IHC-P). GTX01906

Cat. No. GTX01906

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 ES05

Isotype

 IgG1

Application

 IHC-P

Reactivity

 Human
Package
500 μl ($779)
See all MLH1 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
IHC-P 1:50

Note :

IHC-P
The recommended fixative is 10% neutral-buffered formalin for paraffin-embedded tissue sections.
Not tested in other applications.

Calculated MW

85 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

Tissue culture supernatant

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.

Antigen Species

Human

Immunogen

Prokaryotic recombinant protein corresponding to 210 amino acids of human MLH1.

Purification

Unpurified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

mutL homolog 1 , COCA2 , FCC2 , HNPCC , HNPCC2 , hMLH1

Cellular Localization

Nucleus

Background

The protein encoded by this gene can heterodimerize with mismatch repair endonuclease PMS2 to form MutL alpha, part of the DNA mismatch repair system. When MutL alpha is bound by MutS beta and some accessory proteins, the PMS2 subunit of MutL alpha introduces a single-strand break near DNA mismatches, providing an entry point for exonuclease degradation. The encoded protein is also involved in DNA damage signaling and can heterodimerize with DNA mismatch repair protein MLH3 to form MutL gamma, which is involved in meiosis. This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). [provided by RefSeq, Aug 2017]

Database

Research Area

DATA IMAGES

Anti-MLH1 antibody [ES05] used in IHC (Paraffin sections) (IHC-P). GTX01906

GTX01906 IHC-P Image

IHC-P analysis of colorectal carcinoma tissue using GTX01906 MLH1 antibody [ES05]. Note nuclear staining in a high proportion of the malignant cells.

REFERENCE

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REVIEW

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Package List Price ($)
$ 779