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MLKL antibody [8H7]

Anti-MLKL antibody [8H7] used in IHC (Paraffin sections) (IHC-P). GTX34079
Anti-MLKL antibody [8H7] used in IHC (Paraffin sections) (IHC-P). GTX34079

Cat No. GTX34079

Host

Mouse

Clonality

Monoclonal

Clone Name

8H7

Isotype

IgG1

Application

IHC-P

Reactivity

Human
Package
100 μl ($319)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
IHC-P 1:100-1:200
Not tested in other applications.

Calculated MW

54 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS, 50% glycerol, 0.5% BSA, 0.02% sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

synthetic peptide derived from MLKL

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

MLKL,hMLKL,mixed lineage kinase domain like,mixed lineage kinase domain like pseudokinase

Cellular Localization

Cytoplasm,Cell membrane

Background

This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015]

Database

Research Area

DATA IMAGES

Anti-MLKL antibody [8H7] used in IHC (Paraffin sections) (IHC-P). GTX34079

GTX34079 IHC-P Image

IHC-P analysis of human tonsil tissue using GTX34079 MLKL antibody [8H7].
Dilution : 1:200

Anti-MLKL antibody [8H7] used in IHC (Paraffin sections) (IHC-P). GTX34079

GTX34079 IHC-P Image

IHC-P analysis of human skin tissue using GTX34079 MLKL antibody [8H7].
Dilution : 1:200

REFERENCE

There are currently no references for MLKL antibody [8H7] (GTX34079). Be the first to share your publications with this product.

REVIEW

There are currently no reviews for MLKL antibody [8H7] (GTX34079). Be the first to share your experience with this product.
SDS
PBS.pdf
Glycerol.pdf
Sodium Azide.pdf