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MLL antibody [10F8D7]

Anti-MLL antibody [10F8D7] used in Western Blot (WB). GTX83091
Anti-MLL antibody [10F8D7] used in IHC (Paraffin sections) (IHC-P). GTX83091

Cat. No. GTX83091

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 10F8D7

Isotype

 IgG1

Application

 WB, IHC-P, ELISA

Reactivity

 Human
Package
100 μl ($399)
See all MLL products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1/500 - 1/2000
IHC-P 1/200 - 1/1000
ELISA 1/10000
Not tested in other applications.

Calculated MW

432 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

Ascites

Preservative

0.03% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

Purified recombinant fragment of MLL (aa3751-3968) expressed in E. Coli.

Purification

Unpurified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

lysine methyltransferase 2A , ALL-1 , CXXC7 , HRX , HTRX1 , MLL , MLL1 , MLL1A , TRX1 , WDSTS

Cellular Localization

Nucleus

Background

This gene encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. The encoded protein contains multiple conserved functional domains. One of these domains, the SET domain, is responsible for its histone H3 lysine 4 (H3K4) methyltransferase activity which mediates chromatin modifications associated with epigenetic transcriptional activation. This protein is processed by the enzyme Taspase 1 into two fragments, MLL-C and MLL-N. These fragments reassociate and further assemble into different multiprotein complexes that regulate the transcription of specific target genes, including many of the HOX genes. Multiple chromosomal translocations involving this gene are the cause of certain acute lymphoid leukemias and acute myeloid leukemias. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2010]

Database

Research Area

DATA IMAGES

Anti-MLL antibody [10F8D7] used in Western Blot (WB). GTX83091

GTX83091 WB Image

WB analysis of truncated MLL recombinant protein (1) andtruncated GFP-MLL(aa3714-3969) transfected Cos7 cell lysate (2) using GTX83091 MLL antibody [10F8D7].

Anti-MLL antibody [10F8D7] used in IHC (Paraffin sections) (IHC-P). GTX83091

GTX83091 IHC-P Image

IHC-P analysis of human lung cancer (left) and esophagus cancer (right) using GTX83091 MLL antibody [10F8D7].

REFERENCE

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REVIEW

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SDS
Sodium Azide.pdf
Package List Price ($)
$ 399