MMP13 antibody [12E10]

Cat. No. GTX52479

Host	Mouse
Clonality	Monoclonal
Clone Name	12E10
Isotype	IgG1
Application	WB, IHC-P
Reactivity	Human
Package	100 μg ($399)

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Datasheet
Document

View product citations for antibody GTX52479 on CiteAb

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.

Application	Recommended Dilution
WB	1:500 - 1:2000
IHC-P	1:50 - 1:200

Not tested in other applications.

Calculated MW

54 kDa. ( Note )

Product Note

This antibody recognizes human MMP-13 in western blot without cross reactivity with other human MMPs.

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

200 μg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Human recombinant MMP-13

Purification

Protein G purified
From tissue culture supernatant

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

CLG3 , MANDP1 , MDST , MMP13 , matrix metallopeptidase 13

Cellular Localization

Secreted,Extracellular space,Extracellular matrix

Background

This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease cleaves type II collagen more efficiently than types I and III. It may be involved in articular cartilage turnover and cartilage pathophysiology associated with osteoarthritis. Mutations in this gene are associated with metaphyseal anadysplasia. This gene is part of a cluster of MMP genes on chromosome 11. [provided by RefSeq, Jan 2016]

Database

Gene ID: 4322 MMP13
UniProt: P45452 MMP13

Research Area

DATA IMAGES

GTX52479 IHC-P Image

IHC-P analysis of formalin fixed human placenta tissue using GTX52479 MMP13 antibody [12E10]. Proteinase K pretreatment is required.

GTX52479 WB Image

WB analysis of culture supernatant from human chondrocytes after treated without(1) and with(2) FGF2(100ng/ml) for24 hours using GTX52479 MMP13 antibody [12E10].

REFERENCE

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REVIEW

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SDS
PBS.pdf

Package

List Price ($)

100 μg

$ 399

Qty