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MMP17 antibody

Anti-MMP17 antibody used in IHC (Paraffin sections) (IHC-P). GTX29125
Anti-MMP17 antibody used in Western Blot (WB). GTX29125

Cat. No. GTX29125

Reference 1

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC-P

Reactivity

 Human
Package
400 μl ($399)
See all MMP17 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:1000
IHC-P 1:50-1:100
Not tested in other applications.

Calculated MW

67 kDa. ( Note )

Positive Control

Human hepatocarcinoma tissue

Predict Reactivity

Mouse(>80% identity)

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

KLH conjugated synthetic peptide between 391-420 amino acids from the Central region of human MMP17.

Purification

Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

matrix metallopeptidase 17 , MMP-17 , MT4-MMP , MT4MMP , MTMMP4

Background

This gene encodes a member of the peptidase M10 family and membrane-type subfamily of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Members of this subfamily contain a transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. The encoded preproprotein is proteolytically processed to generate the mature protease. This protein is unique among the membrane-type matrix metalloproteinases in that it is anchored to the cell membrane via a glycosylphosphatidylinositol (GPI) anchor. Elevated expression of the encoded protein has been observed in osteoarthritis and multiple human cancers. [provided by RefSeq, Jan 2016]

Database

Research Area

DATA IMAGES

Anti-MMP17 antibody used in IHC (Paraffin sections) (IHC-P). GTX29125

GTX29125 IHC-P Image

IHC-P analysis of human hepatocarcinoma using GTX29125 MMP17 antibody.

Anti-MMP17 antibody used in Western Blot (WB). GTX29125

GTX29125 WB Image

WB analysis of NCI-H460 cell lysate (35ug/lane) using GTX29125 MMP17 antibody.

REFERENCE

Application Reference

Thome I et al. Cancers (Basel) 2020; 12 (9) Neoplastic Cells are the Major Source of MT-MMPs in IDH1-Mutant Glioma, Thus Enhancing Tumor-Cell Intrinsic Brain Infiltration.
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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399