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MMP2 antibody [1H1]

Anti-MMP2 antibody [1H1] used in IHC (Paraffin sections) (IHC-P). GTX34081
Anti-MMP2 antibody [1H1] used in IHC (Paraffin sections) (IHC-P). GTX34081

Cat No. GTX34081

Host Mouse
Clonality Monoclonal
Clone Name 1H1
Isotype IgG1
Application IHC-P
Reactivity Human, Mouse, Rat
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
IHC-P Assay dependent
Not tested in other applications.

Calculated MW

74 kDa. ( Note )

Specificity/Sensitivity

MMP2 Mouse Monoclonal Antibody (1H1) detects endogenous levels of MMP2
PROPERTIES

Form

Liquid

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

Synthetic Peptide of MMP2

Purification

The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Matrix Metallopeptidase 2,Clg4,Clg4A,Mmp-2,Mmp-Ii,Mona,Tbe-1,Mmp2

Background

This gene is a member of the matrix metalloproteinase (MMP) gene family, that are zinc-dependent enzymes capable of cleaving components of the extracellular matrix and molecules involved in signal transduction. The protein encoded by this gene is a gelatinase A, type IV collagenase, that contains three fibronectin type II repeats in its catalytic site that allow binding of denatured type IV and V collagen and elastin. Unlike most MMP family members, activation of this protein can occur on the cell membrane. This enzyme can be activated extracellularly by proteases, or, intracellulary by its S-glutathiolation with no requirement for proteolytical removal of the pro-domain. This protein is thought to be involved in multiple pathways including roles in the nervous system, endometrial menstrual breakdown, regulation of vascularization, and metastasis. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]

Database

Research Area

DATA IMAGES
Anti-MMP2 antibody [1H1] used in IHC (Paraffin sections) (IHC-P). GTX34081

GTX34081 IHC-P Image

Immunohistochemistry (IHC) analysis of paraffin-embedded Human Colon Carcinoma Tissue using MMP2 Mouse Monoclonal Antibody diluted at 1:200.

Anti-MMP2 antibody [1H1] used in IHC (Paraffin sections) (IHC-P). GTX34081

GTX34081 IHC-P Image

Immunohistochemistry (IHC) analysis of paraffin-embedded Human Breast Carcinoma Tissue using MMP2 Mouse Monoclonal Antibody diluted at 1:200.