GeneTex
  • Country / Location Selection

United States (US)

MMP24 antibody

Cat No. GTX11647

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB, IHC-Fr, FACS, IP, ELISA
Reactivity Human, Mouse
Package
25μg ($289)
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1:2,000
IHC-Fr Assay dependent
FACS Assay dependent
IP Assay dependent
ELISA Assay dependent
Not tested in other applications.

Calculated MW

70 kDa. ( Note )

Specificity/Sensitivity

Reacts with native and reduced MMP-24. The antibody recognizes the pro-form of MMP-24 as well as activation/breakdown products. The cytoplasmic domain of MMP-24 is detached when MT-MMPs shed from themselves, thus this antibody should not detect this form of MMP-24.
PROPERTIES

Form

Liquid

Buffer

0.01M PBS pH7.4, 50% glycerol, 15 mM sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

~1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Mouse

Immunogen

synthetic peptide corresponding to the cytoplasmic domain of mouse matrix metalloproteinase-24 (membrane-type matrix metalloproteinase-5)

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Matrix Metallopeptidase 24,Au040325,Mmp-21,Mt5-Mmp,Mt5Mmp,Mtmmp5,Mmp24

Background

Matrix Metalloproteinase 24 (MMP24, MT5MMP) has been described as a proteoglycanase, which is critical in the turnover of ECM (extracellular matrix) components in the brain. MMP24 contains a candidate signal sequence, a propeptide region, a potential furin recognition motif, a zinc-binding catalytic domain, a hemopexin-like domain, a 24-residue hydrophobic region, which acts as a potential transmembrane domain, and a short cytosolic domain. Unlike other MTMMPs, MMP24 (MT5MMP) sheds from the cell surface as soluble proteinases, allowing its versatility as both a cell bound and soluble proteinase in ECM remodeling processes. MMP24 is elevated in several tumor cell lines, and is also produced by some normal cell lines. It is predominantly expressed in the brain, indicating a role in nervous system development. MMP24 is also highly expressed during embryonic development. The mouse MMP24 gene maps to chromosome 2.

Database

Research Area

REFERENCE
There are currently no references for MMP24 antibody (GTX11647).
Be the first to share your publications with this product.
REVIEW
There are currently no reviews for MMP24 antibody (GTX11647).
Be the first to share your experience with this product.
Package List Price ($)
$ 289