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MMP25 antibody [2B5]

Anti-MMP25 antibody [2B5] used in IHC (Paraffin sections) (IHC-P). GTX52482

Cat. No. GTX52482

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 2B5

Isotype

 IgG1

Application

 WB, IHC-P

Reactivity

 Human
Package
100 μg ($399)
See all MMP25 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:1000 - 1:2000
IHC-P 1:50 - 1:500
Not tested in other applications.

Calculated MW

63 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

200 μg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Human recombinant MMP-25

Purification

Protein G purified
From tissue culture supernatant

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

MMP20 , MMP20A , MMP25 , MMPL1 , MT6MMP , MTMMP 6 , MTMMP6 , matrix metallopeptidase 25

Cellular Localization

Cell membrane,Secreted,Extracellular space,Extracellular matrix

Background

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily, attached to the plasma membrane via a glycosylphosphatidyl inositol anchor. In response to bacterial infection or inflammation, the encoded protein is thought to inactivate alpha-1 proteinase inhibitor, a major tissue protectant against proteolytic enzymes released by activated neutrophils, facilitating the transendothelial migration of neutrophils to inflammatory sites. The encoded protein may also play a role in tumor invasion and metastasis through activation of MMP2. The gene has previously been referred to as MMP20 but has been renamed MMP25. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-MMP25 antibody [2B5] used in IHC (Paraffin sections) (IHC-P). GTX52482

GTX52482 IHC-P Image

IHC-P analysis of formalin fixed human placenta tissue using GTX52482 MMP25 antibody [2B5].

REFERENCE

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REVIEW

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SDS
PBS.pdf
Package List Price ($)
$ 399