APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| 1:500 - 1:2000 |
| 1:50 - 1:200 |
| 1:50 - 1:200 |
Not tested in other applications.
Calculated MW
PROPERTIES
Form
Liquid
Buffer
PBS, 50% Glycerol
Preservative
0.02% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
Batch dependent (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
A synthetic peptide of human MMP25
Purification
Purified by affinity chromatography
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
matrix metallopeptidase 25 , MMP-25 , MMP20 , MMP20A , MMPL1 , MT-MMP 6 , MT-MMP6 , MT6-MMP , MT6MMP , MTMMP6
Background
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily, attached to the plasma membrane via a glycosylphosphatidyl inositol anchor. In response to bacterial infection or inflammation, the encoded protein is thought to inactivate alpha-1 proteinase inhibitor, a major tissue protectant against proteolytic enzymes released by activated neutrophils, facilitating the transendothelial migration of neutrophils to inflammatory sites. The encoded protein may also play a role in tumor invasion and metastasis through activation of MMP2. The gene has previously been referred to as MMP20 but has been renamed MMP25. [provided by RefSeq, Jul 2008]
Database
Research Area
DATA IMAGES
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GTX54370 WB Image
WB analysis of various sample lysates using GTX54370 MMP25 antibody.
Dilution : 1:400
Loading : 25μg per lane
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GTX54370 IHC-P Image
IHC-P analysis of human lung cancer tissue using GTX54370 MMP25 antibody.
Dilution : 1:200
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GTX54370 ICC/IF Image
ICC/IF analysis of HeLa cells using GTX54370 MMP25 antibody.
Blue : DAPI
Dilution : 1:100
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GTX54370 IHC-P Image
IHC-P analysis of human rectal cancer tissue using GTX54370 MMP25 antibody.
Dilution : 1:200
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GTX54370 ICC/IF Image
ICC/IF analysis of L929 cells using GTX54370 MMP25 antibody.
Blue : DAPI
Dilution : 1:100
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GTX54370 ICC/IF Image
ICC/IF analysis of C6 cells using GTX54370 MMP25 antibody.
Blue : DAPI
Dilution : 1:100
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REFERENCE
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REVIEW
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