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MMP7 antibody [4C21]

Anti-MMP7 antibody [4C21] used in Western Blot (WB). GTX52475
Anti-MMP7 antibody [4C21] used in IHC (Paraffin sections) (IHC-P). GTX52475

Cat. No. GTX52475

Reference 1

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 4C21

Isotype

 IgG2b

Application

 WB, IHC-P

Reactivity

 Human
Package
100 μg ($399)
See all MMP7 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:500 - 1:2000
IHC-P 1:50 - 1:200
Not tested in other applications.

Calculated MW

30 kDa. ( Note )

Product Note

This antibody recognizes human MMP-7 in western blot without cross reactivity with other human MMPs.

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

200 μg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Human recombinant MMP-7

Purification

Protein G purified
From tissue culture supernatant

Conjugation

Unconjugated

RRID

AB_2887803

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

MMP7 , MPSL1 , PUMP1 , matrix metallopeptidase 7

Cellular Localization

Secreted,Extracellular space,Extracellular matrix

Background

This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal hemopexin domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes on chromosome 11. This gene exhibits elevated expression levels in multiple human cancers. [provided by RefSeq, Jan 2016]

Database

Research Area

DATA IMAGES

Anti-MMP7 antibody [4C21] used in Western Blot (WB). GTX52475

GTX52475 WB Image

WB analysis of SK-OV-3 cell lysates using GTX52475 MMP7 antibody [4C21].

Anti-MMP7 antibody [4C21] used in IHC (Paraffin sections) (IHC-P). GTX52475

GTX52475 IHC-P Image

IHC-P analysis of formalin fixed human placenta tissue using GTX52475 MMP7 antibody [4C21].

REFERENCE

Application Reference

Sato Y et al. Exp Dermatol 2019; (Epub) Malassezia-derived aryl hydrocarbon receptor ligands enhance the CCL20/ Th17/soluble CD163 pathogenic axis in extra-mammary Paget's disease.
Application : WB
Reactivity : Human
Submit a Reference

REVIEW

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SDS
PBS.pdf
Package List Price ($)
$ 399