GeneTex
United States (US)

MRP1 antibody [MRP1/1343]

GTX34850_20170712_IHC-P_3_18121410_627.jpg
GTX34850_20170712_IHC-P_18121410_948.jpg
GTX34850_20170712_IHC-P_1_18121410_640.jpg
GTX34850_20170712_IHC-P_2_18121410_105.jpg

Cat No. GTX34850

Host Mouse
Clonality Monoclonal
Clone Name MRP1/1343
Isotype IgG1
Application IHC-P
Reactivity Human
APPLICATION

Application Note

IHC-P:1-2ug/ml for 30 minutes at RT.

Calculated MW

172 kDa. ( Note )

Specificity/Sensitivity

The two members of the large family of ABC transporters known to confer multidrug resistance in human cancer cells are the MDR1 P-glycoprotein and the multidrug-resistance protein MRP1. MRP1 is an integral membrane protein that contains an MDR-like core, an N-terminal membrane-bound region and a cytoplasmic linker, and it is expressed in various cerebral cells, as well as in lung, testis and peripheral blood.
PROPERTIES

Form

Liquid

Buffer

Prepared in 10mM PBS with 0.05% BSA and 0.05% azide.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

Recombinant human full-length ABCC1

Purification

Ab purified from Bioreactor Concentrate by Protein A/G

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Atp Binding Cassette Subfamily C Member 1,Abc29,Abcc,Gs-X,Mrp,Mrp1,Abcc1

Background

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternatively spliced variants of this gene have been described but their full-length nature is unknown. [provided by RefSeq, Apr 2012]

Database

DATA IMAGES
GTX34850_20170712_IHC-P_3_18121410_627.jpg

GTX34850 IHC-P Image

Formalin-fixed, paraffin-embedded Human Rectal Carcinoma stained with MRP1/ABCC1 Monoclonal Antibody (MRP1/1343).

GTX34850_20170712_IHC-P_18121410_948.jpg

GTX34850 IHC-P Image

Formalin-fixed, paraffin-embedded Human Tonsil stained with MRP1/ABCC1 Monoclonal Antibody (MRP1/1343).

GTX34850_20170712_IHC-P_1_18121410_640.jpg

GTX34850 IHC-P Image

Formalin-fixed, paraffin-embedded Human Pancreas stained with MRP1/ABCC1 Monoclonal Antibody (MRP1/1343).

GTX34850_20170712_IHC-P_2_18121410_105.jpg

GTX34850 IHC-P Image

Formalin-fixed, paraffin-embedded Human Duodenum stained with MRP1/ABCC1 Monoclonal Antibody (MRP1/1343).

Package List Price ($)
$ 329