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MRP1 antibody [QCRL3]

Cat. No. GTX23370

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 QCRL3

Isotype

 IgG2a

Application

 IHC

Reactivity

 Human
Package
250 μl ($399)
See all MRP1 products

APPLICATION

Application Note

IHC: Use at an assay dependent dilution. Optimal dilutions/concentrations should be determined by the end user.

Calculated MW

172 kDa. ( Note )

Positive Control

Cell Lines: Drug sensitive parental cell lines and their multidrug resistant derivatives

Product Note

This antibody detects a 190 kDa transmembrane phosphoglycoprotein overexpressed in various hummation dependent multidrug resistant tumor cell lines. It does not cross react with human MDR1 and MDR3, or mouse MRP gene products.

PROPERTIES

Form

Liquid

Buffer

0.01M PBS, 1% BSA

Preservative

0.1% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Membranes prepared from the human small cell lung cancer cell line H69AR which highly overexpresses MRP

Purification

IgG fraction

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

ATP binding cassette subfamily C member 1 , ABC29 , ABCC , GS-X , MRP , MRP1

Cellular Localization

Cell membrane

Background

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternatively spliced variants of this gene have been described but their full-length nature is unknown. [provided by RefSeq, Apr 2012]

Database

Research Area

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399