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MRP2 antibody [M2I-4]

Cat. No. GTX23372

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 M2I-4

Isotype

 IgG

Application

 WB, ICC/IF, IHC-Fr, FACS

Reactivity

 Human
Package
250 μl ($399)
See all MRP2 products

APPLICATION

Application Note

ICC/IF:Acetone fixed cytospin preparations:Use at a 1:20-1:50 dilution.IHC:Acetone-fixed frozen sections of human tissues:Use at a 1:20 dilution.Follow by incubating with rabbit anti-mouse IgG and a monoclonal mouse APAAP complex.Alternatively,slides can be incubated with biotinylated rabbit anti-mouse IgG and streptavidin conjugated to horseradish peroxidase. WB:Use at a 1:20-1:50 dilution and anti-mouse HRP. Optimal dilutions / concentrations should be determined by the end user.

Calculated MW

174 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS, 1% BSA

Preservative

0.1% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Bacterial fusion protein of human MRP 2 containing amino acids of 215-310.

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

ATP binding cassette subfamily C member 2 , ABC30 , CMOAT , DJS , MRP2 , cMRP

Cellular Localization

Apical cell membrane

Background

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. [provided by RefSeq, Jul 2008]

Database

Research Area

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399