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MRP5 antibody, Internal

Anti-MRP5 antibody, Internal used in Flow cytometry (FACS). GTX81163
Anti-MRP5 antibody, Internal used in IHC (Paraffin sections) (IHC-P). GTX81163
Anti-MRP5 antibody, Internal used in Western Blot (WB). GTX81163

Cat. No. GTX81163

Reference 1

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC-P, FACS

Reactivity

 Human
Package
400 μl ($399)
See all MRP5 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:1000
IHC-P 1:50-1:100
FACS 1:10-1:50
Not tested in other applications.

Calculated MW

161 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

KLH conjugated synthetic peptide between 625-652 amino acids from the Central region of human ABCC5.

Purification

Protein A purified, followed by peptide affinity purification.

Conjugation

Unconjugated

RRID

AB_11164308

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

ATP binding cassette subfamily C member 5 , ABC33 , EST277145 , MOAT-C , MOATC , MRP5 , SMRP , pABC11

Cellular Localization

Membrane; Multi-pass membrane protein

Background

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

Database

Research Area

DATA IMAGES

Anti-MRP5 antibody, Internal used in Flow cytometry (FACS). GTX81163

GTX81163 FACS Image

FACS analysis of 293 cells using GTX81163 MRP5 antibody, Internal.
Top histogram : negative control
Bottom histogram : 293 cells

Anti-MRP5 antibody, Internal used in IHC (Paraffin sections) (IHC-P). GTX81163

GTX81163 IHC-P Image

IHC-P analysis of human brain tissue using GTX81163 MRP5 antibody, Internal.

Anti-MRP5 antibody, Internal used in Western Blot (WB). GTX81163

GTX81163 WB Image

WB analysis of 293 cell lysate (35ug/lane) using GTX81163 MRP5 antibody, Internal.

REFERENCE

Application Reference

Amponsah PS et al. Cancer Lett 2016; microrna-210 overexpression inhibits tumor growth and potentially reverses * resistance in pancreatic cancer.
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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399