GeneTex
United States (US)

MRP5 antibody, N-term

GTX88691_874_IHC-P_18122102_634.jpg
GTX88691_2182_WB_18122102_109.jpg
GTX88691_875_IHC-P_18122102_325.jpg

Cat No. GTX88691

Host Goat
Clonality Polyclonal
Isotype IgG
Application WB, IHC-P
Reactivity Human
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 0.5-1.5μg/ml
IHC-P 4-6μg/ml

Note :

Human Kidney shows membranous staining in DCT. Paraffin embedded Human Liver.
Not tested in other applications.

Calculated MW

161 kDa. ( Note )

Positive Control

The peptide used to generate this antibody is available for purchase (GTX88691-PEP).

Specificity/Sensitivity

This antibody is expected to recognize both reported isoforms (NP_005679.2; NP_001018881.1).

Predict Reactivity

Mouse, Rat, Bovine, Dog, Pig(>80% identity)
PROPERTIES

Form

Liquid

Buffer

Tris saline pH7.3, 0.02% sodium azide, 0.5% BSA.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.50mg/ml

Antigen Species

Human

Immunogen

Peptide with sequence KDIDIGKEYIIP-C, from the N Terminus of the protein sequence according to NP_005679.2; NP_001018881.1.

Purification

Purified by ammonium sulphate precipitation followed by antigen affinity chromatography

Conjugation

Unconjugated

Note

For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

ABCC5 Antibody , MOATC Antibody , SMRP Antibody , EST277145 Antibody , ABC33 Antibody , MOAT C Antibody , PABC11 Antibody

Background

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing of this gene has been detected; however, the complete seq
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Database

DATA IMAGES
GTX88691_874_IHC-P_18122102_634.jpg

GTX88691 IHC-P Image

IHC-P analysis of human kidney using GTX88691 MRP5 antibody, N-term.
Antigen retrieval : citrate buffer pH 6
Dilution : 4µg/ml

GTX88691_2182_WB_18122102_109.jpg

GTX88691 WB Image

WB analysis of human frontal cortex lysate using GTX88691 MRP5 antibody, N-term.
Dilution : 0.5µg/ml
Loading : 35µg protein in RIPA buffer

GTX88691_875_IHC-P_18122102_325.jpg

GTX88691 IHC-P Image

IHC-P analysis of human liver using GTX88691 MRP5 antibody, N-term.
Antigen retrieval : citrate buffer pH 6
Dilution : 5µg/ml

Package List Price ($)
$ 329