APPLICATION
Application Note
Western blotting: use at a dilution of 1/20 to 1/50. FACS: assay dependent. Immunocytochemistry: use at a dilution of 1/20 - 1/50 on acetone fixed cell preparations. Immunohistochemistry: use at a dilution of 1/20 - 1/50 on frozen and formaldehyde-fixed paraffin-embedded tissuesections. Optimal dilutions / concentrations should be determined by the end user. For optimal staining in IHC, the sections should be pretreated with an antigen unmaskingsolution, for example a sodium citrate based buffer. The primary antibodyshould be incubated for about 60 minutes at room temperature when performing IHC.
Calculated MW
Positive Control
Liver, kidney and cell Lines (drug-sensitive parental cell lines and their multidrug-resistant derivatives).
Product Note
This antibody detects with MRP 6. This antibody does not cross-react with MDR 1,MRP 1, MRP 2 or MRP 3, MRP 4 & MRP 5.
PROPERTIES
Form
Liquid
Buffer
Tissue culture supernatant, 1% BSA
Preservative
0.1% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.
Concentration
Batch dependent (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
Bacterial fusion protein of human MRP 6, containing amino acids 764-964, spanning the putative 12th transmembrane region as well as predicted internal and external regions of the protein.
Purification
Tissue culture supernatant
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
ATP binding cassette subfamily C member 6 , ABC34 , ARA , EST349056 , GACI2 , MLP1 , MOAT-E , MOATE , MRP6 , PXE , PXE1 , URG7
Background
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). The encoded protein, a member of the MRP subfamily, is involved in multi-drug resistance. Mutations in this gene cause pseudoxanthoma elasticum. Alternatively spliced transcript variants that encode different proteins have been described for this gene. [provided by RefSeq, Jul 2008]
Database
Research Area
DATA IMAGES
![Anti-MRP6 antibody [M6II-31] used in Immunohistochemistry (IHC). GTX23381](/templates/default/js/lightbox/images/loading.gif "Anti-MRP6 antibody [M6II-31] used in Immunohistochemistry (IHC). GTX23381")
|
GTX23381 IHC Image
MRP 6 Immunohistochemistry
|
REFERENCE
There are currently no references for MRP6 antibody [M6II-31] (GTX23381). Be the first to share your publications with this product.
REVIEW
There are currently no reviews for MRP6 antibody [M6II-31] (GTX23381). Be the first to share your experience with this product.
![Anti-MRP6 antibody [M6II-31] used in Immunohistochemistry (IHC). GTX23381](/upload/website/prouct_img/small/GTX23381/MRP6-antibody-M6II-31-GTX23381-IHC-1_w_23060620_220.webp "Anti-MRP6 antibody [M6II-31] used in Immunohistochemistry (IHC). GTX23381")
![Anti-MRP6 antibody [M6II-31] used in Immunohistochemistry (IHC). GTX23381](/upload/website/prouct_img/normal/GTX23381/MRP6-antibody-M6II-31-GTX23381-IHC-1_w_23060620_220.webp "Anti-MRP6 antibody [M6II-31] used in Immunohistochemistry (IHC). GTX23381")