GeneTex
United States (US)

MSH2 antibody [2MSH01]

MSH2-antibody-2MSH01_IHC_GTX30741-1_18121411_576.jpg
img18136_18121411_175.jpg

Cat No. GTX30741

Host Mouse
Clonality Monoclonal
Clone Name 2MSH01
Isotype IgG1
Application IHC-P, IHC
Reactivity Human
APPLICATION

Application Note

For IHC-P: Use at a dilution of 1:25. Optimal dilutions/concentrations should be determined by the end user.

Calculated MW

105 kDa. ( Note )

Positive Control

Human tonsil tissue
PROPERTIES

Form

Liquid

Buffer

Tissue culture supernatant containing 15mM sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Tissue culture supernatant

Antigen Species

Human

Immunogen

Recombinant MSH2 protein

Purification

Unpurified

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Muts Homolog 2,Coca1,Fcc1,Hnpcc,Hnpcc1,Lcfs2,Hmsh2,Msh2

Background

MSH2 is involved in DNA repair as a mismatch repair protein, and mutations of MSH2 are found in approximately 50% of inherited non polyposis colorectal carcinoma (HNPCC) (Lynch syndrome) cases. HNPCC is an autosomal, dominantly inherited disease associated with marked increase in cancer susceptibility. It is characterized by a familial predisposition to early onset colorectal carcinoma and extra-colonic cancers of the gastrointestinal, urological and female reproductive tracts. HNPCC is reported to be the most common form of inherited colorectal cancer in the western world.

Database

Research Area

DATA IMAGES
MSH2-antibody-2MSH01_IHC_GTX30741-1_18121411_576.jpg

GTX30741 IHC-P Image

Immunohistochemical staining using MSH2 antibody on formalin fixed, paraffin embedded human tonsil tissue.

img18136_18121411_175.jpg

GTX30741 IHC Image