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MSH2 antibody [G219-1129]

Cat. No. GTX01748

Reference 5

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 G219-1129

Isotype

 IgG1

Application

 WB, IHC-P

Reactivity

 Human
Package
500 μl ($429)
See all MSH2 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB Assay dependent
IHC-P 1:50-1:100

Note :

IHC-P
Pretreatment of deparaffinized tissue with heat-induced epitope retrieval or enzymatic retrieval is recommended.
Not tested in other applications.

Calculated MW

105 kDa. ( Note )

Positive Control

Colon carcinoma

PROPERTIES

Form

Liquid

Buffer

Tris-HCl buffer, 0.2% BSA

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

BALB/C mice were injected with recombinant human MSH2 protein

Purification

Purified IgG

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

mutS homolog 2 , COCA1 , FCC1 , HNPCC , HNPCC1 , LCFS2 , hMSH2

Cellular Localization

Nucleus

Background

This locus is frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

Database

Research Area

REFERENCE

Clone Reference

2020; A Novel Germline MLH1 In-Frame Deletion in a Slovenian Lynch Syndrome Family Associated with Uncommon Isolated PMS2 Loss in Tumor Tissue
Application : IHC-P
Reactivity : Human
2019; Molecular classification of endometrial carcinoma applied to endometrial biopsy specimens: Towards early personalized patient management
Application : IHC-P
2019; Coping with formalin banning in pathology: under vacuum long-term tissue storage with no added formalin
Application : IHC-P
Reactivity : Human
2019; Screening for microsatellite instability in colorectal carcinoma: Practical utility of immunohistochemistry and PCR with fragment analysis in a diagnostic histopathology setting
Application : IHC-P
Reactivity : Human
2019; Inflammation-Associated Microsatellite Alterations Caused by MSH3 Dysfunction Are Prevalent in Ulcerative Colitis and Increase With Neoplastic Advancement
Application : WB
Reactivity : Human
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REVIEW

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Package List Price ($)
$ 429