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MSH2 antibody [MSVA-902M] HistoMAX™

Recombinant antibody HistoMAX
Anti-MSH2 antibody [MSVA-902M] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04408
Anti-MSH2 antibody [MSVA-902M] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04408
Anti-MSH2 antibody [MSVA-902M] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04408

Cat. No. GTX04408

Host

Mouse

Clonality

Monoclonal

Clone Name

MSVA-902M

Isotype

IgG2a

Application

IHC-P

Reactivity

Human
Package
500 μl ($679),
100 μl ($299)
PRODUCT

Summary

This antibody was validated on 76 different Normal Tissues by IHC-P.

Go to Normal Tissue GalleryGo to Cancer Tissue Gallery

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
IHC-P 1:100-1:200

Note :

IHC-P
Manual staining : Heat-induced antigen retrieval for 5 minutes in an autoclave at 121ºC in pH 7.8 Tris-EDTA-based Target Retrieval Solution buffer.

This antibody has been validated by Autostainer including Agilent/Dako - Autostainer Link 48 and BOND RX - Leica. The detailed steps by Autostainer please refer to the protocol.

Not tested in other applications.

Calculated MW

105 kDa. ( Note )

Positive Control

Tonsil: Virtually all mantle zone B-cells must show an at least weak to moderate nuclear staining. A moderate to strong nuclear staining must be seen in the germinal centre B-cells.

Negative Control

Colon adenocarcinoma with previously documented loss of MSH2 expression: no nuclear staining should be seen in cancer cells, while a nuclear staining must be seen in stromal and inflammatory cells.

PROPERTIES

Form

Liquid

Buffer

PBS, 0.05% BSA (Please contact us for PBS only format)

Preservative

0.05% sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.2 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant full-length human MSH2 protein

Purification

Protein A/G purified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

mutS homolog 2 , COCA1 , FCC1 , HNPCC , HNPCC1 , LCFS2 , hMSH2

Cellular Localization

Nucleus

Background

This locus is frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

Database

Research Area

DATA IMAGES

Anti-MSH2 antibody [MSVA-902M] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04408

GTX04408 IHC-P Image

IHC-P analysis of human ovarian malignant mixed Müllerian tumor (MMMT) tissue using GTX04408 MSH2 antibody [MSVA-902M] HistoMAX™.
Malignant Mixed Mullerian tumor with strong MSH2 positivity in stromal and inflammatory cells but absence of staining in tumor cells.

Anti-MSH2 antibody [MSVA-902M] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04408

GTX04408 IHC-P Image

IHC-P analysis of human colorectal adenocarcinoma (COAD) tissue using GTX04408 MSH2 antibody [MSVA-902M] HistoMAX™.
Colorectal adenocarcinoma with strong MSH2 immunostaining in cancer cells and in stromal cells.

Anti-MSH2 antibody [MSVA-902M] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04408

GTX04408 IHC-P Image

IHC-P analysis of human tonsil tissue using GTX04408 MSH2 antibody [MSVA-902M] HistoMAX™.

REFERENCE

There are currently no references for MSH2 antibody [MSVA-902M] HistoMAX™ (GTX04408). Be the first to share your publications with this product.

REVIEW

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Package List Price ($)
$ 679
$ 299