GeneTex
United States (US)

MSH5 antibody, Internal

GTX88660_843_IHC-P_18121411_756.jpg

Cat No. GTX88660

Host Goat
Clonality Polyclonal
Isotype IgG
Application IHC-P
Reactivity Human
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
IHC-P 2.5-3.8μg/ml

Note :

Human Testis shows nuclear staining in spermatocytes.
Not tested in other applications.

Calculated MW

93 kDa. ( Note )

Positive Control

The peptide used to generate this antibody is available for purchase (GTX88660-PEP).

Specificity/Sensitivity

This antibody is expected to recognise three reported isoforms ( NP_079535.3 ; NP_751897.1; NP_002432.1)

Predict Reactivity

Mouse, Rat(>80% identity)
PROPERTIES

Form

Liquid

Buffer

Tris saline pH7.3, 0.02% sodium azide, 0.5% BSA.

Concentration

0.50mg/ml

Antigen Species

Human

Immunogen

Peptide with sequence GDLHCEIRDQET, from the internal region of the protein sequence according to NP_079535.3 ; NP_751897.1; NP_002432.1.

Purification

Purified by ammonium sulphate precipitation followed by antigen affinity chromatography

Conjugation

Unconjugated

Note

For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

MUTSH5 Antibody , G7 Antibody , NG23 Antibody

Background

This gene encodes a member of the mutS family of proteins that are involved in DNA mismatch repair and meiotic recombination. This protein is similar to a Saccharomyces cerevisiae protein that participates in segregation fidelity and crossing-over events during meiosis. This protein plays a role in promoting ionizing radiation-induced apoptosis. This protein forms hetero-oligomers with another member of this family, mutS homolog 4. Polymorphisms in this gene have been linked to various human diseases, including IgA deficiency, common variable immunodeficiency, and premature ovarian failure. Alternative splicing results multiple transcript variants. Read-through transcription also exists between this gene and the downstream chromosome 6 open reading frame 26 (C6orf26) gene. [provided by RefSeq, Feb 2011]
Show More +

Database

Research Area

DATA IMAGES
GTX88660_843_IHC-P_18121411_756.jpg

GTX88660 IHC-P Image

IHC-P analysis of human testis using GTX88660 MSH5 antibody, Internal.
Antigen retrieval : citrate buffer pH 6
Dilution : 3.8µg/ml